Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CCL15

Gene summary for CCL15

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CCL15

Gene ID

6359

Gene nameC-C motif chemokine ligand 15
Gene AliasHCC-2
Cytomap17q12
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

A0A0B4J2E2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6359CCL15HTA11_3410_2000001011HumanColorectumAD4.20e-029.21e-020.0155
6359CCL15HTA11_2487_2000001011HumanColorectumSER5.89e-297.65e-01-0.1808
6359CCL15HTA11_1938_2000001011HumanColorectumAD3.43e-083.09e-01-0.0811
6359CCL15HTA11_78_2000001011HumanColorectumAD2.35e-062.05e-01-0.1088
6359CCL15HTA11_347_2000001011HumanColorectumAD8.33e-366.96e-01-0.1954
6359CCL15HTA11_411_2000001011HumanColorectumSER1.35e-128.27e-01-0.2602
6359CCL15HTA11_2112_2000001011HumanColorectumSER1.88e-137.74e-01-0.2196
6359CCL15HTA11_3361_2000001011HumanColorectumAD7.49e-103.40e-01-0.1207
6359CCL15HTA11_83_2000001011HumanColorectumSER2.83e-156.16e-01-0.1526
6359CCL15HTA11_696_2000001011HumanColorectumAD1.28e-346.36e-01-0.1464
6359CCL15HTA11_866_2000001011HumanColorectumAD3.52e-133.16e-01-0.1001
6359CCL15HTA11_1391_2000001011HumanColorectumAD1.00e-143.93e-01-0.059
6359CCL15HTA11_2992_2000001011HumanColorectumSER2.40e-136.78e-01-0.1706
6359CCL15HTA11_5212_2000001011HumanColorectumAD2.50e-187.78e-01-0.2061
6359CCL15HTA11_5216_2000001011HumanColorectumSER3.03e-065.85e-01-0.1462
6359CCL15HTA11_546_2000001011HumanColorectumAD4.83e-052.15e-01-0.0842
6359CCL15HTA11_7862_2000001011HumanColorectumAD2.45e-144.97e-01-0.0179
6359CCL15HTA11_866_3004761011HumanColorectumAD2.47e-041.30e-010.096
6359CCL15HTA11_8622_2000001021HumanColorectumSER3.15e-093.65e-010.0528
6359CCL15HTA11_7663_2000001011HumanColorectumSER6.70e-114.54e-010.0131
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0043087ColorectumADregulation of GTPase activity110/3918348/187231.64e-065.03e-05110
GO:0043547ColorectumADpositive regulation of GTPase activity75/3918255/187237.95e-047.91e-0375
GO:00430871ColorectumSERregulation of GTPase activity77/2897348/187235.90e-048.07e-0377
GO:00430872ColorectumMSSregulation of GTPase activity101/3467348/187231.00e-063.46e-05101
GO:00435471ColorectumMSSpositive regulation of GTPase activity68/3467255/187237.97e-048.38e-0368
GO:0034341ColorectumMSI-Hresponse to interferon-gamma21/1319141/187238.78e-041.57e-0221
GO:00343411LiverHCCresponse to interferon-gamma82/7958141/187231.25e-041.03e-0382
GO:00713461LiverHCCcellular response to interferon-gamma70/7958118/187231.66e-041.32e-0370
GO:00705551LiverHCCresponse to interleukin-180/7958143/187237.95e-044.77e-0380
GO:003461211LiverHCCresponse to tumor necrosis factor132/7958253/187231.14e-036.48e-03132
GO:00713471LiverHCCcellular response to interleukin-161/7958113/187238.98e-033.46e-0261
GO:007135611LiverHCCcellular response to tumor necrosis factor115/7958229/187231.08e-023.99e-02115
GO:0071356StomachGCcellular response to tumor necrosis factor34/1159229/187231.85e-068.24e-0534
GO:0034612StomachGCresponse to tumor necrosis factor35/1159253/187236.68e-062.54e-0435
GO:0071621StomachGCgranulocyte chemotaxis22/1159125/187237.88e-062.80e-0422
GO:0030595StomachGCleukocyte chemotaxis32/1159230/187231.45e-054.68e-0432
GO:0050900StomachGCleukocyte migration44/1159369/187232.30e-056.81e-0444
GO:0097530StomachGCgranulocyte migration23/1159148/187233.99e-051.00e-0323
GO:0030593StomachGCneutrophil chemotaxis18/1159103/187235.67e-051.31e-0318
GO:0097529StomachGCmyeloid leukocyte migration29/1159220/187239.69e-051.97e-0329
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
CCL15CCR1CCL15_CCR1CCLCRCAD
CCL15CCR1CCL15_CCR1CCLLungAAH
CCL15CCR1CCL15_CCR1CCLLungPrecancer
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CCL15SNVMissense_Mutationrs551984257c.315N>Ap.Met105Ilep.M105IQ16663protein_codingtolerated(0.47)benign(0.101)TCGA-BH-A0B6-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
CCL15SNVMissense_Mutationnovelc.176N>Tp.Ser59Leup.S59LQ16663protein_codingdeleterious(0.03)benign(0.131)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
CCL15SNVMissense_Mutationnovelc.66G>Cp.Gln22Hisp.Q22HQ16663protein_codingtolerated(0.37)benign(0.323)TCGA-AG-3726-01Colorectumrectum adenocarcinomaFemale<65I/IIUnknownUnknownSD
CCL15SNVMissense_Mutationnovelc.37N>Ap.Leu13Ilep.L13IQ16663protein_codingdeleterious(0.05)benign(0.359)TCGA-AX-A2HD-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
CCL15SNVMissense_Mutationnovelc.332N>Gp.Tyr111Cysp.Y111CQ16663protein_codingtolerated_low_confidence(0.15)benign(0.033)TCGA-AX-A3FT-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
CCL15SNVMissense_Mutationnovelc.56C>Ap.Ser19Tyrp.S19YQ16663protein_codingdeleterious(0.01)probably_damaging(0.98)TCGA-B5-A0JY-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapydoxorubicinSD
CCL15SNVMissense_Mutationrs551984257c.315N>Ap.Met105Ilep.M105IQ16663protein_codingtolerated(0.47)benign(0.101)TCGA-4R-AA8I-01Liverliver hepatocellular carcinomaMale>=65I/IIUnknownUnknownPD
CCL15SNVMissense_Mutationnovelc.201G>Ap.Met67Ilep.M67IQ16663protein_codingtolerated(0.08)benign(0.225)TCGA-05-4410-01Lunglung adenocarcinomaMale<65I/IIUnknownUnknownSD
CCL15SNVMissense_Mutationnovelc.154G>Ap.Asp52Asnp.D52NQ16663protein_codingdeleterious(0)probably_damaging(0.974)TCGA-44-5644-01Lunglung adenocarcinomaFemale<65I/IIUnknownUnknownSD
CCL15SNVMissense_Mutationnovelc.175N>Cp.Ser59Prop.S59PQ16663protein_codingtolerated(0.97)benign(0.001)TCGA-44-6146-01Lunglung adenocarcinomaMale<65I/IIChemotherapyalimtaPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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