Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CCDC85B

Gene summary for CCDC85B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CCDC85B

Gene ID

11007

Gene namecoiled-coil domain containing 85B
Gene AliasDIPA
Cytomap11q13.1
Gene Typeprotein-coding
GO ID

GO:0001558

UniProtAcc

Q15834


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11007CCDC85BCA_HPV_1HumanCervixCC7.58e-12-1.75e-010.0264
11007CCDC85BN_HPV_1HumanCervixN_HPV4.13e-025.67e-020.0079
11007CCDC85BCCI_1HumanCervixCC4.39e-07-5.19e-010.528
11007CCDC85BCCI_3HumanCervixCC7.49e-04-4.42e-010.516
11007CCDC85BCCII_1HumanCervixCC3.54e-11-5.07e-010.3249
11007CCDC85BH2HumanCervixHSIL_HPV6.52e-04-2.57e-010.0632
11007CCDC85BL1HumanCervixCC1.67e-04-1.35e-010.0802
11007CCDC85BHTA11_696_2000001011HumanColorectumAD2.26e-021.62e-01-0.1464
11007CCDC85BHTA11_1391_2000001011HumanColorectumAD1.97e-124.11e-01-0.059
11007CCDC85BHTA11_866_3004761011HumanColorectumAD9.27e-092.78e-010.096
11007CCDC85BHTA11_4255_2000001011HumanColorectumSER1.47e-022.88e-010.0446
11007CCDC85BHTA11_7696_3000711011HumanColorectumAD2.03e-052.49e-010.0674
11007CCDC85BHTA11_6818_2000001011HumanColorectumAD4.67e-042.18e-010.0112
11007CCDC85BHTA11_6818_2000001021HumanColorectumAD2.34e-114.89e-010.0588
11007CCDC85BHTA11_99999970781_79442HumanColorectumMSS1.81e-103.07e-010.294
11007CCDC85BHTA11_99999965104_69814HumanColorectumMSS9.62e-042.15e-010.281
11007CCDC85BHTA11_99999971662_82457HumanColorectumMSS3.22e-531.06e+000.3859
11007CCDC85BHTA11_99999973899_84307HumanColorectumMSS5.44e-033.15e-010.2585
11007CCDC85BHTA11_99999974143_84620HumanColorectumMSS1.36e-225.56e-010.3005
11007CCDC85BA002-C-116HumanColorectumFAP7.81e-033.17e-01-0.0452
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00454445CervixCCfat cell differentiation53/2311229/187233.72e-069.75e-0553
GO:00160498CervixCCcell growth92/2311482/187231.16e-052.49e-0492
GO:00015588CervixCCregulation of cell growth77/2311414/187231.40e-041.70e-0377
GO:0045598CervixCCregulation of fat cell differentiation31/2311139/187237.06e-046.41e-0331
GO:001604914CervixHSIL_HPVcell growth32/737482/187232.87e-032.70e-0232
GO:004544413CervixHSIL_HPVfat cell differentiation18/737229/187234.27e-033.64e-0218
GO:0016049ColorectumADcell growth143/3918482/187232.83e-068.09e-05143
GO:0001558ColorectumADregulation of cell growth124/3918414/187237.67e-061.86e-04124
GO:0045926ColorectumADnegative regulation of growth70/3918249/187234.07e-032.83e-0270
GO:00015581ColorectumSERregulation of cell growth90/2897414/187234.00e-046.02e-0390
GO:00160491ColorectumSERcell growth100/2897482/187231.07e-031.24e-02100
GO:00459261ColorectumSERnegative regulation of growth55/2897249/187233.44e-032.92e-0255
GO:0045444ColorectumSERfat cell differentiation51/2897229/187233.96e-033.26e-0251
GO:00160492ColorectumMSScell growth123/3467482/187237.15e-051.21e-03123
GO:00015582ColorectumMSSregulation of cell growth105/3467414/187232.97e-043.90e-03105
GO:00160493ColorectumFAPcell growth112/2622482/187232.40e-082.30e-06112
GO:00015583ColorectumFAPregulation of cell growth95/2622414/187235.02e-072.61e-0595
GO:00160494ColorectumCRCcell growth95/2078482/187231.51e-082.75e-0695
GO:00015584ColorectumCRCregulation of cell growth78/2078414/187231.84e-069.11e-0578
GO:00160499EndometriumAEHcell growth93/2100482/187231.00e-074.99e-0693
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CCDC85BSNVMissense_Mutationnovelc.533N>Cp.Leu178Prop.L178PQ15834protein_codingtolerated(0.26)possibly_damaging(0.539)TCGA-43-8115-01Lunglung squamous cell carcinomaFemale>=65I/IIChemotherapycarboplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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