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Gene: CCDC82 |
Gene summary for CCDC82 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CCDC82 | Gene ID | 79780 |
Gene name | coiled-coil domain containing 82 | |
Gene Alias | HSPC048 | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R3B3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79780 | CCDC82 | LZE4T | Human | Esophagus | ESCC | 1.88e-04 | 1.76e-01 | 0.0811 |
79780 | CCDC82 | LZE7T | Human | Esophagus | ESCC | 6.60e-04 | 2.00e-01 | 0.0667 |
79780 | CCDC82 | LZE8T | Human | Esophagus | ESCC | 1.02e-02 | 1.78e-01 | 0.067 |
79780 | CCDC82 | LZE24T | Human | Esophagus | ESCC | 1.04e-16 | 2.51e-01 | 0.0596 |
79780 | CCDC82 | LZE6T | Human | Esophagus | ESCC | 9.48e-03 | 1.85e-01 | 0.0845 |
79780 | CCDC82 | P1T-E | Human | Esophagus | ESCC | 6.99e-04 | 2.47e-01 | 0.0875 |
79780 | CCDC82 | P2T-E | Human | Esophagus | ESCC | 1.36e-06 | 1.59e-01 | 0.1177 |
79780 | CCDC82 | P4T-E | Human | Esophagus | ESCC | 4.74e-18 | 4.10e-01 | 0.1323 |
79780 | CCDC82 | P5T-E | Human | Esophagus | ESCC | 2.93e-04 | 1.56e-01 | 0.1327 |
79780 | CCDC82 | P8T-E | Human | Esophagus | ESCC | 9.12e-05 | 1.11e-01 | 0.0889 |
79780 | CCDC82 | P9T-E | Human | Esophagus | ESCC | 6.67e-10 | 1.87e-01 | 0.1131 |
79780 | CCDC82 | P10T-E | Human | Esophagus | ESCC | 1.76e-11 | 2.68e-01 | 0.116 |
79780 | CCDC82 | P11T-E | Human | Esophagus | ESCC | 3.71e-08 | 3.10e-01 | 0.1426 |
79780 | CCDC82 | P12T-E | Human | Esophagus | ESCC | 1.07e-15 | 3.68e-01 | 0.1122 |
79780 | CCDC82 | P15T-E | Human | Esophagus | ESCC | 1.68e-08 | 1.03e-01 | 0.1149 |
79780 | CCDC82 | P16T-E | Human | Esophagus | ESCC | 3.58e-22 | 3.43e-01 | 0.1153 |
79780 | CCDC82 | P17T-E | Human | Esophagus | ESCC | 7.45e-05 | 3.76e-01 | 0.1278 |
79780 | CCDC82 | P19T-E | Human | Esophagus | ESCC | 1.81e-02 | 2.79e-01 | 0.1662 |
79780 | CCDC82 | P20T-E | Human | Esophagus | ESCC | 2.37e-09 | 9.92e-02 | 0.1124 |
79780 | CCDC82 | P21T-E | Human | Esophagus | ESCC | 8.61e-21 | 4.54e-01 | 0.1617 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC82 | SNV | Missense_Mutation | novel | c.808C>A | p.Pro270Thr | p.P270T | Q8N4S0 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
CCDC82 | SNV | Missense_Mutation | c.685N>A | p.Glu229Lys | p.E229K | Q8N4S0 | protein_coding | deleterious(0.04) | probably_damaging(0.934) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CCDC82 | SNV | Missense_Mutation | c.73N>T | p.Asp25Tyr | p.D25Y | Q8N4S0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C8-A12U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC82 | SNV | Missense_Mutation | c.1162C>G | p.Arg388Gly | p.R388G | Q8N4S0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC82 | insertion | Nonsense_Mutation | novel | c.76_77insAGCACAG | p.Trp26Ter | p.W26* | Q8N4S0 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
CCDC82 | insertion | Frame_Shift_Ins | novel | c.75_76insATATATATCCCCATTTCTCTTGCATC | p.Trp26IlefsTer71 | p.W26Ifs*71 | Q8N4S0 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
CCDC82 | insertion | Nonsense_Mutation | novel | c.1411_1412insTGTAAATACTGTGTGTAAAACTGTTACAAGTGACAGTTGTATGT | p.Arg471LeufsTer2 | p.R471Lfs*2 | Q8N4S0 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CCDC82 | deletion | Frame_Shift_Del | c.739_754delNNNNNNNNNNNNNNNN | p.Ser247ValfsTer48 | p.S247Vfs*48 | Q8N4S0 | protein_coding | TCGA-BH-A0BL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |||
CCDC82 | SNV | Missense_Mutation | c.1468N>C | p.Cys490Arg | p.C490R | Q8N4S0 | protein_coding | tolerated(0.05) | benign(0.09) | TCGA-A6-6140-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | SD | |
CCDC82 | SNV | Missense_Mutation | c.815G>A | p.Ser272Asn | p.S272N | Q8N4S0 | protein_coding | tolerated(0.25) | benign(0) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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