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Gene: CCDC68 |
Gene summary for CCDC68 |
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Gene information | Species | Human | Gene symbol | CCDC68 | Gene ID | 80323 |
Gene name | coiled-coil domain containing 68 | |
Gene Alias | SE57-1 | |
Cytomap | 18q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A0A024R2B9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80323 | CCDC68 | LZE24T | Human | Esophagus | ESCC | 1.16e-02 | 2.16e-01 | 0.0596 |
80323 | CCDC68 | P5T-E | Human | Esophagus | ESCC | 1.37e-03 | 1.39e-01 | 0.1327 |
80323 | CCDC68 | P8T-E | Human | Esophagus | ESCC | 2.32e-14 | 3.61e-01 | 0.0889 |
80323 | CCDC68 | P11T-E | Human | Esophagus | ESCC | 1.27e-02 | 9.20e-02 | 0.1426 |
80323 | CCDC68 | P23T-E | Human | Esophagus | ESCC | 1.75e-03 | 1.03e-01 | 0.108 |
80323 | CCDC68 | P31T-E | Human | Esophagus | ESCC | 9.35e-03 | 6.67e-02 | 0.1251 |
80323 | CCDC68 | P32T-E | Human | Esophagus | ESCC | 7.25e-05 | 1.19e-01 | 0.1666 |
80323 | CCDC68 | P37T-E | Human | Esophagus | ESCC | 2.06e-08 | 6.37e-02 | 0.1371 |
80323 | CCDC68 | P57T-E | Human | Esophagus | ESCC | 6.68e-03 | 6.09e-02 | 0.0926 |
80323 | CCDC68 | P62T-E | Human | Esophagus | ESCC | 8.23e-03 | 9.13e-02 | 0.1302 |
80323 | CCDC68 | P74T-E | Human | Esophagus | ESCC | 4.18e-06 | 1.26e-01 | 0.1479 |
80323 | CCDC68 | P75T-E | Human | Esophagus | ESCC | 4.36e-11 | 2.51e-01 | 0.1125 |
80323 | CCDC68 | P82T-E | Human | Esophagus | ESCC | 2.73e-12 | 5.84e-01 | 0.1072 |
80323 | CCDC68 | P83T-E | Human | Esophagus | ESCC | 8.89e-12 | 2.92e-01 | 0.1738 |
80323 | CCDC68 | P89T-E | Human | Esophagus | ESCC | 9.74e-07 | 2.24e-01 | 0.1752 |
80323 | CCDC68 | P94T-E | Human | Esophagus | ESCC | 1.20e-02 | 6.46e-01 | 0.0879 |
80323 | CCDC68 | P104T-E | Human | Esophagus | ESCC | 2.21e-08 | 5.98e-01 | 0.0931 |
80323 | CCDC68 | P107T-E | Human | Esophagus | ESCC | 2.70e-06 | 1.16e-01 | 0.171 |
80323 | CCDC68 | HCC1_Meng | Human | Liver | HCC | 1.33e-47 | 8.66e-02 | 0.0246 |
80323 | CCDC68 | HCC2_Meng | Human | Liver | HCC | 4.33e-11 | 8.92e-02 | 0.0107 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC68 | SNV | Missense_Mutation | novel | c.199N>T | p.Ala67Ser | p.A67S | Q9H2F9 | protein_coding | tolerated(0.46) | benign(0.007) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
CCDC68 | SNV | Missense_Mutation | rs201370562 | c.77C>T | p.Thr26Met | p.T26M | Q9H2F9 | protein_coding | deleterious(0) | possibly_damaging(0.707) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC68 | insertion | In_Frame_Ins | novel | c.629_630insTTTCCATCTGCCCTGCCACATCACGAACAAATATGCAGG | p.Leu210_Ser211insPheHisLeuProCysHisIleThrAsnLysTyrAlaGly | p.L210_S211insFHLPCHITNKYAG | Q9H2F9 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
CCDC68 | deletion | Frame_Shift_Del | novel | c.552delN | p.Lys184AsnfsTer23 | p.K184Nfs*23 | Q9H2F9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CCDC68 | SNV | Missense_Mutation | rs773131156 | c.644N>G | p.Lys215Arg | p.K215R | Q9H2F9 | protein_coding | tolerated(0.16) | probably_damaging(0.974) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCDC68 | SNV | Missense_Mutation | rs141183307 | c.1000N>T | p.Arg334Trp | p.R334W | Q9H2F9 | protein_coding | deleterious(0.02) | probably_damaging(0.918) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC68 | deletion | Frame_Shift_Del | novel | c.599delA | p.Lys200ArgfsTer7 | p.K200Rfs*7 | Q9H2F9 | protein_coding | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | ||
CCDC68 | SNV | Missense_Mutation | c.286N>C | p.Lys96Gln | p.K96Q | Q9H2F9 | protein_coding | deleterious(0.01) | possibly_damaging(0.548) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCDC68 | SNV | Missense_Mutation | novel | c.324N>T | p.Glu108Asp | p.E108D | Q9H2F9 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC68 | SNV | Missense_Mutation | novel | c.408A>C | p.Glu136Asp | p.E136D | Q9H2F9 | protein_coding | tolerated(0.22) | benign(0.036) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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