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Gene: CCDC59 |
Gene summary for CCDC59 |
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Gene information | Species | Human | Gene symbol | CCDC59 | Gene ID | 29080 |
Gene name | coiled-coil domain containing 59 | |
Gene Alias | BR22 | |
Cytomap | 12q21.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9P031 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29080 | CCDC59 | LZE2D | Human | Esophagus | HGIN | 6.30e-06 | 1.46e-01 | 0.0642 |
29080 | CCDC59 | LZE4T | Human | Esophagus | ESCC | 1.89e-10 | 1.83e-01 | 0.0811 |
29080 | CCDC59 | LZE7T | Human | Esophagus | ESCC | 9.75e-12 | 1.02e+00 | 0.0667 |
29080 | CCDC59 | LZE8T | Human | Esophagus | ESCC | 4.25e-09 | 1.76e-01 | 0.067 |
29080 | CCDC59 | LZE20T | Human | Esophagus | ESCC | 4.85e-09 | 2.29e-01 | 0.0662 |
29080 | CCDC59 | LZE22D1 | Human | Esophagus | HGIN | 1.14e-04 | 2.07e-02 | 0.0595 |
29080 | CCDC59 | LZE22T | Human | Esophagus | ESCC | 6.18e-05 | -3.87e-03 | 0.068 |
29080 | CCDC59 | LZE24T | Human | Esophagus | ESCC | 8.42e-10 | 4.53e-01 | 0.0596 |
29080 | CCDC59 | LZE6T | Human | Esophagus | ESCC | 8.27e-04 | 2.27e-01 | 0.0845 |
29080 | CCDC59 | P1T-E | Human | Esophagus | ESCC | 2.56e-12 | 6.61e-01 | 0.0875 |
29080 | CCDC59 | P2T-E | Human | Esophagus | ESCC | 1.32e-62 | 1.21e+00 | 0.1177 |
29080 | CCDC59 | P4T-E | Human | Esophagus | ESCC | 1.71e-33 | 1.14e+00 | 0.1323 |
29080 | CCDC59 | P5T-E | Human | Esophagus | ESCC | 2.57e-47 | 9.90e-01 | 0.1327 |
29080 | CCDC59 | P8T-E | Human | Esophagus | ESCC | 7.67e-30 | 7.81e-01 | 0.0889 |
29080 | CCDC59 | P9T-E | Human | Esophagus | ESCC | 1.72e-15 | 4.65e-01 | 0.1131 |
29080 | CCDC59 | P10T-E | Human | Esophagus | ESCC | 3.24e-26 | 5.81e-01 | 0.116 |
29080 | CCDC59 | P11T-E | Human | Esophagus | ESCC | 2.73e-15 | 7.03e-01 | 0.1426 |
29080 | CCDC59 | P12T-E | Human | Esophagus | ESCC | 6.80e-23 | 5.83e-01 | 0.1122 |
29080 | CCDC59 | P15T-E | Human | Esophagus | ESCC | 4.50e-37 | 8.30e-01 | 0.1149 |
29080 | CCDC59 | P16T-E | Human | Esophagus | ESCC | 1.98e-35 | 7.77e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC59 | insertion | In_Frame_Ins | novel | c.89_90insTCT | p.Lys30delinsAsnLeu | p.K30delinsNL | Q9P031 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
CCDC59 | insertion | Frame_Shift_Ins | novel | c.88_89insCTAGA | p.Lys30ThrfsTer5 | p.K30Tfs*5 | Q9P031 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
CCDC59 | SNV | Missense_Mutation | rs763980491 | c.148N>T | p.Arg50Cys | p.R50C | Q9P031 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
CCDC59 | SNV | Missense_Mutation | c.296N>A | p.Ala99Asp | p.A99D | Q9P031 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CCDC59 | SNV | Missense_Mutation | novel | c.654N>T | p.Lys218Asn | p.K218N | Q9P031 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC59 | SNV | Missense_Mutation | novel | c.495N>T | p.Lys165Asn | p.K165N | Q9P031 | protein_coding | tolerated(0.08) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC59 | SNV | Missense_Mutation | novel | c.47A>G | p.Glu16Gly | p.E16G | Q9P031 | protein_coding | tolerated(1) | benign(0) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
CCDC59 | insertion | Frame_Shift_Ins | novel | c.487_488insTATATTTAGG | p.Asn163IlefsTer5 | p.N163Ifs*5 | Q9P031 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CCDC59 | insertion | Frame_Shift_Ins | novel | c.709_710insA | p.Ile237AsnfsTer20 | p.I237Nfs*20 | Q9P031 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CCDC59 | SNV | Missense_Mutation | rs150615186 | c.547C>T | p.Arg183Cys | p.R183C | Q9P031 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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