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Gene: CCDC174 |
Gene summary for CCDC174 |
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Gene information | Species | Human | Gene symbol | CCDC174 | Gene ID | 51244 |
Gene name | coiled-coil domain containing 174 | |
Gene Alias | C3orf19 | |
Cytomap | 3p25.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6PII3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51244 | CCDC174 | LZE4T | Human | Esophagus | ESCC | 5.92e-08 | 1.81e-01 | 0.0811 |
51244 | CCDC174 | LZE7T | Human | Esophagus | ESCC | 2.12e-04 | 1.61e-01 | 0.0667 |
51244 | CCDC174 | LZE20T | Human | Esophagus | ESCC | 1.53e-03 | 6.05e-02 | 0.0662 |
51244 | CCDC174 | LZE24T | Human | Esophagus | ESCC | 9.80e-17 | 3.51e-01 | 0.0596 |
51244 | CCDC174 | LZE6T | Human | Esophagus | ESCC | 3.65e-07 | 2.55e-01 | 0.0845 |
51244 | CCDC174 | P1T-E | Human | Esophagus | ESCC | 1.15e-04 | 2.60e-01 | 0.0875 |
51244 | CCDC174 | P2T-E | Human | Esophagus | ESCC | 9.46e-20 | 2.85e-01 | 0.1177 |
51244 | CCDC174 | P4T-E | Human | Esophagus | ESCC | 4.15e-21 | 3.73e-01 | 0.1323 |
51244 | CCDC174 | P5T-E | Human | Esophagus | ESCC | 1.42e-30 | 5.51e-01 | 0.1327 |
51244 | CCDC174 | P8T-E | Human | Esophagus | ESCC | 2.98e-15 | 3.29e-01 | 0.0889 |
51244 | CCDC174 | P9T-E | Human | Esophagus | ESCC | 1.28e-13 | 2.68e-01 | 0.1131 |
51244 | CCDC174 | P10T-E | Human | Esophagus | ESCC | 2.92e-16 | 3.31e-01 | 0.116 |
51244 | CCDC174 | P11T-E | Human | Esophagus | ESCC | 1.59e-04 | 2.65e-01 | 0.1426 |
51244 | CCDC174 | P12T-E | Human | Esophagus | ESCC | 1.77e-17 | 4.18e-01 | 0.1122 |
51244 | CCDC174 | P15T-E | Human | Esophagus | ESCC | 1.39e-13 | 1.93e-01 | 0.1149 |
51244 | CCDC174 | P16T-E | Human | Esophagus | ESCC | 4.44e-17 | 3.38e-01 | 0.1153 |
51244 | CCDC174 | P17T-E | Human | Esophagus | ESCC | 4.68e-07 | 4.26e-01 | 0.1278 |
51244 | CCDC174 | P19T-E | Human | Esophagus | ESCC | 1.86e-03 | 1.80e-01 | 0.1662 |
51244 | CCDC174 | P20T-E | Human | Esophagus | ESCC | 7.93e-22 | 4.23e-01 | 0.1124 |
51244 | CCDC174 | P21T-E | Human | Esophagus | ESCC | 3.43e-18 | 2.62e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC174 | SNV | Missense_Mutation | c.644N>C | p.Arg215Pro | p.R215P | Q6PII3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC174 | SNV | Missense_Mutation | c.25N>A | p.Asp9Asn | p.D9N | Q6PII3 | protein_coding | tolerated(0.31) | benign(0.047) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CCDC174 | SNV | Missense_Mutation | rs758812410 | c.764N>A | p.Arg255Gln | p.R255Q | Q6PII3 | protein_coding | tolerated(0.44) | benign(0.02) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC174 | insertion | Frame_Shift_Ins | novel | c.948_949insTATTTGCTTGA | p.Arg317TyrfsTer32 | p.R317Yfs*32 | Q6PII3 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
CCDC174 | SNV | Missense_Mutation | c.1342G>A | p.Ala448Thr | p.A448T | Q6PII3 | protein_coding | tolerated(0.45) | benign(0.007) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC174 | SNV | Missense_Mutation | rs201187132 | c.71N>A | p.Arg24Gln | p.R24Q | Q6PII3 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCDC174 | SNV | Missense_Mutation | novel | c.231N>T | p.Lys77Asn | p.K77N | Q6PII3 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC174 | SNV | Missense_Mutation | novel | c.629N>T | p.Arg210Ile | p.R210I | Q6PII3 | protein_coding | deleterious(0.04) | probably_damaging(0.94) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC174 | SNV | Missense_Mutation | c.804G>T | p.Glu268Asp | p.E268D | Q6PII3 | protein_coding | tolerated(1) | benign(0.013) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CCDC174 | SNV | Missense_Mutation | c.593N>G | p.Pro198Arg | p.P198R | Q6PII3 | protein_coding | tolerated(0.1) | benign(0.132) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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