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Gene: CCDC167 |
Gene summary for CCDC167 |
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Gene information | Species | Human | Gene symbol | CCDC167 | Gene ID | 154467 |
Gene name | coiled-coil domain containing 167 | |
Gene Alias | C6orf129 | |
Cytomap | 6p21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9P0B6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
154467 | CCDC167 | LZE2T | Human | Esophagus | ESCC | 4.19e-08 | 9.19e-01 | 0.082 |
154467 | CCDC167 | LZE4T | Human | Esophagus | ESCC | 3.04e-10 | 3.25e-01 | 0.0811 |
154467 | CCDC167 | LZE5T | Human | Esophagus | ESCC | 3.44e-04 | 3.69e-01 | 0.0514 |
154467 | CCDC167 | LZE7T | Human | Esophagus | ESCC | 2.13e-13 | 5.73e-01 | 0.0667 |
154467 | CCDC167 | LZE8T | Human | Esophagus | ESCC | 4.01e-09 | 2.71e-01 | 0.067 |
154467 | CCDC167 | LZE20T | Human | Esophagus | ESCC | 5.69e-10 | 2.86e-01 | 0.0662 |
154467 | CCDC167 | LZE22D1 | Human | Esophagus | HGIN | 3.00e-03 | 1.36e-01 | 0.0595 |
154467 | CCDC167 | LZE22T | Human | Esophagus | ESCC | 5.71e-05 | 4.44e-01 | 0.068 |
154467 | CCDC167 | LZE24T | Human | Esophagus | ESCC | 4.33e-14 | 3.21e-01 | 0.0596 |
154467 | CCDC167 | LZE21T | Human | Esophagus | ESCC | 4.61e-03 | 4.82e-01 | 0.0655 |
154467 | CCDC167 | LZE6T | Human | Esophagus | ESCC | 8.45e-19 | 7.48e-01 | 0.0845 |
154467 | CCDC167 | P1T-E | Human | Esophagus | ESCC | 8.51e-14 | 6.24e-01 | 0.0875 |
154467 | CCDC167 | P2T-E | Human | Esophagus | ESCC | 1.46e-25 | 5.06e-01 | 0.1177 |
154467 | CCDC167 | P4T-E | Human | Esophagus | ESCC | 3.68e-32 | 7.53e-01 | 0.1323 |
154467 | CCDC167 | P5T-E | Human | Esophagus | ESCC | 9.79e-25 | 4.89e-01 | 0.1327 |
154467 | CCDC167 | P8T-E | Human | Esophagus | ESCC | 1.07e-23 | 3.75e-01 | 0.0889 |
154467 | CCDC167 | P9T-E | Human | Esophagus | ESCC | 1.40e-23 | 4.33e-01 | 0.1131 |
154467 | CCDC167 | P10T-E | Human | Esophagus | ESCC | 2.06e-26 | 4.22e-01 | 0.116 |
154467 | CCDC167 | P11T-E | Human | Esophagus | ESCC | 2.45e-13 | 4.92e-01 | 0.1426 |
154467 | CCDC167 | P12T-E | Human | Esophagus | ESCC | 9.47e-32 | 5.58e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC167 | SNV | Missense_Mutation | c.76C>T | p.Arg26Trp | p.R26W | Q9P0B6 | protein_coding | deleterious(0.01) | possibly_damaging(0.87) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
CCDC167 | SNV | Missense_Mutation | rs202216795 | c.115N>T | p.Arg39Trp | p.R39W | Q9P0B6 | protein_coding | deleterious(0.01) | benign(0.409) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CCDC167 | SNV | Missense_Mutation | rs764902665 | c.290N>C | p.Met97Thr | p.M97T | Q9P0B6 | protein_coding | deleterious(0) | benign(0) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC167 | SNV | Missense_Mutation | rs746959044 | c.140N>A | p.Arg47Lys | p.R47K | Q9P0B6 | protein_coding | tolerated(0.96) | benign(0.003) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC167 | SNV | Missense_Mutation | rs138745679 | c.271N>A | p.Val91Ile | p.V91I | Q9P0B6 | protein_coding | tolerated(1) | benign(0) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CCDC167 | SNV | Missense_Mutation | rs781100483 | c.46N>A | p.Asp16Asn | p.D16N | Q9P0B6 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC167 | SNV | Missense_Mutation | novel | c.248C>T | p.Ala83Val | p.A83V | Q9P0B6 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-44-6147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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