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Gene: CCDC157 |
Gene summary for CCDC157 |
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Gene information | Species | Human | Gene symbol | CCDC157 | Gene ID | 550631 |
Gene name | coiled-coil domain containing 157 | |
Gene Alias | CCDC157 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q569K6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
550631 | CCDC157 | HCC1_Meng | Human | Liver | HCC | 3.88e-04 | -3.65e-02 | 0.0246 |
550631 | CCDC157 | HCC1 | Human | Liver | HCC | 1.04e-13 | 1.86e+00 | 0.5336 |
550631 | CCDC157 | HCC2 | Human | Liver | HCC | 2.17e-28 | 2.89e+00 | 0.5341 |
550631 | CCDC157 | HCC5 | Human | Liver | HCC | 8.23e-18 | 1.89e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC157 | SNV | Missense_Mutation | rs149837002 | c.814N>A | p.Val272Met | p.V272M | Q569K6 | protein_coding | tolerated(0.82) | benign(0.031) | TCGA-OL-A5S0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | CR |
CCDC157 | deletion | Frame_Shift_Del | novel | c.553delC | p.Gln185LysfsTer67 | p.Q185Kfs*67 | Q569K6 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CCDC157 | SNV | Missense_Mutation | rs763055857 | c.667N>A | p.Ala223Thr | p.A223T | Q569K6 | protein_coding | tolerated(0.42) | possibly_damaging(0.556) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCDC157 | SNV | Missense_Mutation | rs763703415 | c.2047N>T | p.Arg683Trp | p.R683W | Q569K6 | protein_coding | deleterious_low_confidence(0.01) | benign(0.082) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
CCDC157 | SNV | Missense_Mutation | c.256C>A | p.Leu86Met | p.L86M | Q569K6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-6650-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC157 | SNV | Missense_Mutation | rs201598906 | c.1657N>A | p.Glu553Lys | p.E553K | Q569K6 | protein_coding | deleterious(0.03) | benign(0.017) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC157 | SNV | Missense_Mutation | rs369961135 | c.1618N>T | p.Arg540Trp | p.R540W | Q569K6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
CCDC157 | SNV | Missense_Mutation | novel | c.1615G>A | p.Glu539Lys | p.E539K | Q569K6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC157 | SNV | Missense_Mutation | rs750607091 | c.133N>T | p.Arg45Cys | p.R45C | Q569K6 | protein_coding | deleterious(0) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CCDC157 | SNV | Missense_Mutation | rs370198354 | c.679G>A | p.Val227Ile | p.V227I | Q569K6 | protein_coding | tolerated(0.2) | possibly_damaging(0.536) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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