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Gene: CCDC146 |
Gene summary for CCDC146 |
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Gene information | Species | Human | Gene symbol | CCDC146 | Gene ID | 57639 |
Gene name | coiled-coil domain containing 146 | |
Gene Alias | MBO2 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IYE0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57639 | CCDC146 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.53e-29 | -8.00e-01 | 0.0155 |
57639 | CCDC146 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.14e-17 | -8.05e-01 | -0.1808 |
57639 | CCDC146 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.31e-04 | -8.36e-01 | 0.0216 |
57639 | CCDC146 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.24e-10 | -7.40e-01 | -0.0811 |
57639 | CCDC146 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.03e-13 | -6.97e-01 | -0.1088 |
57639 | CCDC146 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.47e-24 | -7.48e-01 | -0.1954 |
57639 | CCDC146 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.38e-04 | -8.65e-01 | -0.2196 |
57639 | CCDC146 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.38e-14 | -8.04e-01 | -0.1207 |
57639 | CCDC146 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.34e-13 | -8.56e-01 | -0.1526 |
57639 | CCDC146 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.22e-28 | -7.25e-01 | -0.1464 |
57639 | CCDC146 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.73e-31 | -7.63e-01 | -0.1001 |
57639 | CCDC146 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.76e-10 | -6.17e-01 | -0.059 |
57639 | CCDC146 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.54e-06 | -8.74e-01 | -0.1706 |
57639 | CCDC146 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.09e-07 | -8.52e-01 | -0.2061 |
57639 | CCDC146 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.56e-07 | -9.03e-01 | -0.1462 |
57639 | CCDC146 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.80e-05 | -6.28e-01 | -0.0842 |
57639 | CCDC146 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.89e-02 | -8.57e-01 | -0.00410000000000005 |
57639 | CCDC146 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.54e-07 | -7.61e-01 | -0.0179 |
57639 | CCDC146 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.92e-21 | -7.61e-01 | 0.096 |
57639 | CCDC146 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.32e-04 | -7.41e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC146 | SNV | Missense_Mutation | rs765660008 | c.1751N>C | p.Met584Thr | p.M584T | Q8IYE0 | protein_coding | deleterious(0) | benign(0.19) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
CCDC146 | SNV | Missense_Mutation | c.340G>A | p.Glu114Lys | p.E114K | Q8IYE0 | protein_coding | deleterious(0.01) | possibly_damaging(0.545) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
CCDC146 | SNV | Missense_Mutation | c.210N>C | p.Lys70Asn | p.K70N | Q8IYE0 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
CCDC146 | SNV | Missense_Mutation | c.65A>G | p.Glu22Gly | p.E22G | Q8IYE0 | protein_coding | deleterious(0.02) | benign(0.025) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC146 | SNV | Missense_Mutation | c.2558C>A | p.Ser853Tyr | p.S853Y | Q8IYE0 | protein_coding | tolerated(0.37) | possibly_damaging(0.627) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC146 | SNV | Missense_Mutation | c.328N>C | p.Asp110His | p.D110H | Q8IYE0 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
CCDC146 | SNV | Missense_Mutation | c.1064N>A | p.Arg355Lys | p.R355K | Q8IYE0 | protein_coding | tolerated(0.14) | benign(0.172) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
CCDC146 | deletion | Frame_Shift_Del | novel | c.1580_1587delNNNNNNNN | p.Phe528LeufsTer11 | p.F528Lfs*11 | Q8IYE0 | protein_coding | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CCDC146 | SNV | Missense_Mutation | c.1565N>A | p.Arg522Gln | p.R522Q | Q8IYE0 | protein_coding | tolerated(0.66) | benign(0.198) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
CCDC146 | SNV | Missense_Mutation | c.1627N>C | p.Lys543Gln | p.K543Q | Q8IYE0 | protein_coding | deleterious(0.02) | benign(0.158) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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