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Gene: CCDC142 |
Gene summary for CCDC142 |
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Gene information | Species | Human | Gene symbol | CCDC142 | Gene ID | 84865 |
Gene name | coiled-coil domain containing 142 | |
Gene Alias | CCDC142 | |
Cytomap | 2p13.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q17RM4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84865 | CCDC142 | HCC1_Meng | Human | Liver | HCC | 9.33e-12 | -4.15e-02 | 0.0246 |
84865 | CCDC142 | HCC1 | Human | Liver | HCC | 8.91e-22 | 4.29e+00 | 0.5336 |
84865 | CCDC142 | HCC2 | Human | Liver | HCC | 2.68e-38 | 3.55e+00 | 0.5341 |
84865 | CCDC142 | HCC5 | Human | Liver | HCC | 3.67e-25 | 3.20e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC142 | SNV | Missense_Mutation | c.179N>T | p.Pro60Leu | p.P60L | Q17RM4 | protein_coding | tolerated_low_confidence(0.2) | benign(0) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CCDC142 | SNV | Missense_Mutation | novel | c.595N>G | p.Ser199Ala | p.S199A | Q17RM4 | protein_coding | tolerated(0.17) | benign(0.08) | TCGA-E2-A15L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CCDC142 | SNV | Missense_Mutation | c.1133N>G | p.Ala378Gly | p.A378G | Q17RM4 | protein_coding | tolerated(0.27) | benign(0.034) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
CCDC142 | SNV | Missense_Mutation | novel | c.706C>A | p.Leu236Ile | p.L236I | Q17RM4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCDC142 | SNV | Missense_Mutation | c.665N>C | p.His222Pro | p.H222P | Q17RM4 | protein_coding | tolerated(0.18) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CCDC142 | SNV | Missense_Mutation | c.1372N>G | p.Leu458Val | p.L458V | Q17RM4 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC142 | SNV | Missense_Mutation | novel | c.513N>G | p.Ile171Met | p.I171M | Q17RM4 | protein_coding | deleterious_low_confidence(0.01) | benign(0.443) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCDC142 | SNV | Missense_Mutation | c.607N>A | p.Ala203Thr | p.A203T | Q17RM4 | protein_coding | tolerated_low_confidence(0.09) | benign(0.288) | TCGA-AA-3494-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PR | |
CCDC142 | SNV | Missense_Mutation | novel | c.1319C>T | p.Ala440Val | p.A440V | Q17RM4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CCDC142 | SNV | Missense_Mutation | rs761087638 | c.1586N>A | p.Arg529His | p.R529H | Q17RM4 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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