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Gene: CCDC127 |
Gene summary for CCDC127 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CCDC127 | Gene ID | 133957 |
Gene name | coiled-coil domain containing 127 | |
Gene Alias | CCDC127 | |
Cytomap | 5p15.33 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96BQ5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
133957 | CCDC127 | LZE8T | Human | Esophagus | ESCC | 1.92e-03 | 1.50e-01 | 0.067 |
133957 | CCDC127 | LZE20T | Human | Esophagus | ESCC | 9.10e-10 | 3.48e-01 | 0.0662 |
133957 | CCDC127 | LZE22T | Human | Esophagus | ESCC | 2.40e-03 | 2.85e-01 | 0.068 |
133957 | CCDC127 | LZE24T | Human | Esophagus | ESCC | 1.22e-06 | 1.61e-01 | 0.0596 |
133957 | CCDC127 | LZE6T | Human | Esophagus | ESCC | 1.88e-05 | 3.18e-01 | 0.0845 |
133957 | CCDC127 | P1T-E | Human | Esophagus | ESCC | 4.39e-02 | 2.08e-01 | 0.0875 |
133957 | CCDC127 | P2T-E | Human | Esophagus | ESCC | 1.69e-11 | 3.05e-01 | 0.1177 |
133957 | CCDC127 | P4T-E | Human | Esophagus | ESCC | 2.64e-26 | 6.36e-01 | 0.1323 |
133957 | CCDC127 | P5T-E | Human | Esophagus | ESCC | 1.30e-28 | 5.80e-01 | 0.1327 |
133957 | CCDC127 | P8T-E | Human | Esophagus | ESCC | 2.60e-18 | 3.43e-01 | 0.0889 |
133957 | CCDC127 | P9T-E | Human | Esophagus | ESCC | 1.64e-03 | 1.70e-01 | 0.1131 |
133957 | CCDC127 | P10T-E | Human | Esophagus | ESCC | 1.06e-22 | 4.83e-01 | 0.116 |
133957 | CCDC127 | P11T-E | Human | Esophagus | ESCC | 1.48e-12 | 6.34e-01 | 0.1426 |
133957 | CCDC127 | P12T-E | Human | Esophagus | ESCC | 8.62e-23 | 4.57e-01 | 0.1122 |
133957 | CCDC127 | P15T-E | Human | Esophagus | ESCC | 2.57e-11 | 2.59e-01 | 0.1149 |
133957 | CCDC127 | P16T-E | Human | Esophagus | ESCC | 4.75e-10 | 1.68e-01 | 0.1153 |
133957 | CCDC127 | P17T-E | Human | Esophagus | ESCC | 4.31e-09 | 3.50e-01 | 0.1278 |
133957 | CCDC127 | P19T-E | Human | Esophagus | ESCC | 1.38e-03 | 3.54e-01 | 0.1662 |
133957 | CCDC127 | P20T-E | Human | Esophagus | ESCC | 7.87e-14 | 3.18e-01 | 0.1124 |
133957 | CCDC127 | P21T-E | Human | Esophagus | ESCC | 1.08e-28 | 6.41e-01 | 0.1617 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC127 | SNV | Missense_Mutation | c.619N>T | p.Ala207Ser | p.A207S | Q96BQ5 | protein_coding | tolerated(0.72) | benign(0.007) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
CCDC127 | SNV | Missense_Mutation | novel | c.692G>A | p.Gly231Asp | p.G231D | Q96BQ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC127 | SNV | Missense_Mutation | c.485N>C | p.Phe162Ser | p.F162S | Q96BQ5 | protein_coding | deleterious(0.01) | benign(0.099) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CCDC127 | SNV | Missense_Mutation | novel | c.385N>A | p.Gln129Lys | p.Q129K | Q96BQ5 | protein_coding | tolerated(0.29) | benign(0) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CCDC127 | SNV | Missense_Mutation | c.331N>T | p.Arg111Cys | p.R111C | Q96BQ5 | protein_coding | deleterious(0) | benign(0.005) | TCGA-DM-A28H-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
CCDC127 | deletion | Frame_Shift_Del | c.522delC | p.Cys174Ter | p.C174* | Q96BQ5 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
CCDC127 | SNV | Missense_Mutation | c.584N>G | p.Ser195Cys | p.S195C | Q96BQ5 | protein_coding | deleterious(0.02) | possibly_damaging(0.518) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC127 | SNV | Missense_Mutation | c.583N>A | p.Ser195Thr | p.S195T | Q96BQ5 | protein_coding | tolerated(0.28) | benign(0.053) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC127 | SNV | Missense_Mutation | c.336N>T | p.Lys112Asn | p.K112N | Q96BQ5 | protein_coding | deleterious(0.02) | benign(0.307) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC127 | SNV | Missense_Mutation | novel | c.188C>A | p.Thr63Asn | p.T63N | Q96BQ5 | protein_coding | tolerated(0.26) | possibly_damaging(0.656) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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