Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CCDC127

Gene summary for CCDC127

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CCDC127

Gene ID

133957

Gene namecoiled-coil domain containing 127
Gene AliasCCDC127
Cytomap5p15.33
Gene Typeprotein-coding
GO ID

NA

UniProtAcc

Q96BQ5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
133957CCDC127LZE8THumanEsophagusESCC1.92e-031.50e-010.067
133957CCDC127LZE20THumanEsophagusESCC9.10e-103.48e-010.0662
133957CCDC127LZE22THumanEsophagusESCC2.40e-032.85e-010.068
133957CCDC127LZE24THumanEsophagusESCC1.22e-061.61e-010.0596
133957CCDC127LZE6THumanEsophagusESCC1.88e-053.18e-010.0845
133957CCDC127P1T-EHumanEsophagusESCC4.39e-022.08e-010.0875
133957CCDC127P2T-EHumanEsophagusESCC1.69e-113.05e-010.1177
133957CCDC127P4T-EHumanEsophagusESCC2.64e-266.36e-010.1323
133957CCDC127P5T-EHumanEsophagusESCC1.30e-285.80e-010.1327
133957CCDC127P8T-EHumanEsophagusESCC2.60e-183.43e-010.0889
133957CCDC127P9T-EHumanEsophagusESCC1.64e-031.70e-010.1131
133957CCDC127P10T-EHumanEsophagusESCC1.06e-224.83e-010.116
133957CCDC127P11T-EHumanEsophagusESCC1.48e-126.34e-010.1426
133957CCDC127P12T-EHumanEsophagusESCC8.62e-234.57e-010.1122
133957CCDC127P15T-EHumanEsophagusESCC2.57e-112.59e-010.1149
133957CCDC127P16T-EHumanEsophagusESCC4.75e-101.68e-010.1153
133957CCDC127P17T-EHumanEsophagusESCC4.31e-093.50e-010.1278
133957CCDC127P19T-EHumanEsophagusESCC1.38e-033.54e-010.1662
133957CCDC127P20T-EHumanEsophagusESCC7.87e-143.18e-010.1124
133957CCDC127P21T-EHumanEsophagusESCC1.08e-286.41e-010.1617
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CCDC127SNVMissense_Mutationc.619N>Tp.Ala207Serp.A207SQ96BQ5protein_codingtolerated(0.72)benign(0.007)TCGA-A1-A0SO-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapySD
CCDC127SNVMissense_Mutationnovelc.692G>Ap.Gly231Aspp.G231DQ96BQ5protein_codingdeleterious(0)probably_damaging(1)TCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CCDC127SNVMissense_Mutationc.485N>Cp.Phe162Serp.F162SQ96BQ5protein_codingdeleterious(0.01)benign(0.099)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
CCDC127SNVMissense_Mutationnovelc.385N>Ap.Gln129Lysp.Q129KQ96BQ5protein_codingtolerated(0.29)benign(0)TCGA-AA-A02E-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownPD
CCDC127SNVMissense_Mutationc.331N>Tp.Arg111Cysp.R111CQ96BQ5protein_codingdeleterious(0)benign(0.005)TCGA-DM-A28H-01Colorectumcolon adenocarcinomaMale<65III/IVUnknownUnknownPD
CCDC127deletionFrame_Shift_Delc.522delCp.Cys174Terp.C174*Q96BQ5protein_codingTCGA-AA-3715-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
CCDC127SNVMissense_Mutationc.584N>Gp.Ser195Cysp.S195CQ96BQ5protein_codingdeleterious(0.02)possibly_damaging(0.518)TCGA-A5-A0GH-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
CCDC127SNVMissense_Mutationc.583N>Ap.Ser195Thrp.S195TQ96BQ5protein_codingtolerated(0.28)benign(0.053)TCGA-A5-A0GH-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
CCDC127SNVMissense_Mutationc.336N>Tp.Lys112Asnp.K112NQ96BQ5protein_codingdeleterious(0.02)benign(0.307)TCGA-A5-A0VP-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
CCDC127SNVMissense_Mutationnovelc.188C>Ap.Thr63Asnp.T63NQ96BQ5protein_codingtolerated(0.26)possibly_damaging(0.656)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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