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Gene: CCDC117 |
Gene summary for CCDC117 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCDC117 | Gene ID | 150275 |
| Gene name | coiled-coil domain containing 117 | |
| Gene Alias | dJ366L4.1 | |
| Cytomap | 22q12.1 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8IWD4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 150275 | CCDC117 | LZE4T | Human | Esophagus | ESCC | 3.57e-05 | 1.72e-01 | 0.0811 |
| 150275 | CCDC117 | LZE24T | Human | Esophagus | ESCC | 5.58e-13 | 2.57e-01 | 0.0596 |
| 150275 | CCDC117 | LZE21T | Human | Esophagus | ESCC | 1.91e-02 | 2.81e-01 | 0.0655 |
| 150275 | CCDC117 | P1T-E | Human | Esophagus | ESCC | 2.08e-04 | 3.24e-01 | 0.0875 |
| 150275 | CCDC117 | P2T-E | Human | Esophagus | ESCC | 3.38e-20 | 2.59e-01 | 0.1177 |
| 150275 | CCDC117 | P4T-E | Human | Esophagus | ESCC | 4.71e-16 | 2.93e-01 | 0.1323 |
| 150275 | CCDC117 | P5T-E | Human | Esophagus | ESCC | 3.96e-02 | 4.61e-02 | 0.1327 |
| 150275 | CCDC117 | P8T-E | Human | Esophagus | ESCC | 1.26e-11 | 1.62e-01 | 0.0889 |
| 150275 | CCDC117 | P9T-E | Human | Esophagus | ESCC | 2.68e-11 | 2.06e-01 | 0.1131 |
| 150275 | CCDC117 | P10T-E | Human | Esophagus | ESCC | 2.25e-17 | 3.34e-01 | 0.116 |
| 150275 | CCDC117 | P11T-E | Human | Esophagus | ESCC | 6.17e-16 | 4.74e-01 | 0.1426 |
| 150275 | CCDC117 | P12T-E | Human | Esophagus | ESCC | 3.40e-24 | 4.49e-01 | 0.1122 |
| 150275 | CCDC117 | P15T-E | Human | Esophagus | ESCC | 1.49e-17 | 3.20e-01 | 0.1149 |
| 150275 | CCDC117 | P16T-E | Human | Esophagus | ESCC | 2.64e-16 | 2.32e-01 | 0.1153 |
| 150275 | CCDC117 | P19T-E | Human | Esophagus | ESCC | 9.68e-05 | 3.04e-01 | 0.1662 |
| 150275 | CCDC117 | P20T-E | Human | Esophagus | ESCC | 5.32e-13 | 2.15e-01 | 0.1124 |
| 150275 | CCDC117 | P22T-E | Human | Esophagus | ESCC | 4.43e-16 | 2.91e-01 | 0.1236 |
| 150275 | CCDC117 | P23T-E | Human | Esophagus | ESCC | 3.55e-13 | 3.47e-01 | 0.108 |
| 150275 | CCDC117 | P24T-E | Human | Esophagus | ESCC | 1.14e-07 | 1.35e-01 | 0.1287 |
| 150275 | CCDC117 | P26T-E | Human | Esophagus | ESCC | 1.64e-11 | 2.78e-01 | 0.1276 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CCDC117 | SNV | Missense_Mutation | c.325N>C | p.Glu109Gln | p.E109Q | Q8IWD4 | protein_coding | tolerated(0.2) | benign(0.017) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| CCDC117 | SNV | Missense_Mutation | c.223N>C | p.Glu75Gln | p.E75Q | Q8IWD4 | protein_coding | tolerated(0.19) | possibly_damaging(0.776) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| CCDC117 | SNV | Missense_Mutation | c.284N>T | p.Ala95Val | p.A95V | Q8IWD4 | protein_coding | tolerated(0.52) | benign(0.127) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCDC117 | SNV | Missense_Mutation | c.231N>T | p.Glu77Asp | p.E77D | Q8IWD4 | protein_coding | tolerated(0.56) | benign(0.011) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| CCDC117 | SNV | Missense_Mutation | c.231G>T | p.Glu77Asp | p.E77D | Q8IWD4 | protein_coding | tolerated(0.56) | benign(0.011) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCDC117 | SNV | Missense_Mutation | c.590N>G | p.Met197Arg | p.M197R | Q8IWD4 | protein_coding | deleterious(0) | benign(0.22) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| CCDC117 | SNV | Missense_Mutation | c.235G>T | p.Asp79Tyr | p.D79Y | Q8IWD4 | protein_coding | deleterious(0.01) | possibly_damaging(0.873) | TCGA-F4-6855-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCDC117 | SNV | Missense_Mutation | c.766C>T | p.Pro256Ser | p.P256S | Q8IWD4 | protein_coding | tolerated(0.17) | benign(0.11) | TCGA-AG-3881-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCDC117 | SNV | Missense_Mutation | novel | c.785C>A | p.Ser262Tyr | p.S262Y | Q8IWD4 | protein_coding | deleterious(0.01) | possibly_damaging(0.542) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| CCDC117 | SNV | Missense_Mutation | novel | c.208A>G | p.Lys70Glu | p.K70E | Q8IWD4 | protein_coding | deleterious(0) | possibly_damaging(0.475) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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