![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CCDC113 |
Gene summary for CCDC113 |
![]() |
Gene information | Species | Human | Gene symbol | CCDC113 | Gene ID | 29070 |
Gene name | coiled-coil domain containing 113 | |
Gene Alias | HSPC065 | |
Cytomap | 16q21 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9H0I3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29070 | CCDC113 | HCC1 | Human | Liver | HCC | 6.74e-03 | 3.12e+00 | 0.5336 |
29070 | CCDC113 | HCC2 | Human | Liver | HCC | 1.46e-17 | 3.24e+00 | 0.5341 |
29070 | CCDC113 | S028 | Human | Liver | HCC | 6.24e-04 | 2.10e-01 | 0.2503 |
29070 | CCDC113 | S029 | Human | Liver | HCC | 1.81e-07 | 2.78e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC113 | insertion | Frame_Shift_Ins | novel | c.857_858insCCCAAGTTTAGAGAGGTTCTGGGACCTCCCCAGAGATCTCCTT | p.Glu286AspfsTer18 | p.E286Dfs*18 | Q9H0I3 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CCDC113 | insertion | Frame_Shift_Ins | novel | c.318_319insTA | p.Glu107Ter | p.E107* | Q9H0I3 | protein_coding | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CCDC113 | insertion | Nonsense_Mutation | novel | c.319_320insGTTGCGGACATGAAGGATGACTTACGACACACA | p.Glu107delinsGlyCysGlyHisGluGlyTerLeuThrThrHisLys | p.E107delinsGCGHEG*LTTHK | Q9H0I3 | protein_coding | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CCDC113 | SNV | Missense_Mutation | c.767T>C | p.Val256Ala | p.V256A | Q9H0I3 | protein_coding | deleterious(0.02) | benign(0.253) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
CCDC113 | SNV | Missense_Mutation | rs765930226 | c.292N>A | p.Asp98Asn | p.D98N | Q9H0I3 | protein_coding | deleterious(0.02) | possibly_damaging(0.557) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC113 | SNV | Missense_Mutation | rs780838577 | c.973G>A | p.Val325Ile | p.V325I | Q9H0I3 | protein_coding | tolerated(0.06) | benign(0.03) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CCDC113 | SNV | Missense_Mutation | rs372103092 | c.431N>T | p.Ser144Leu | p.S144L | Q9H0I3 | protein_coding | deleterious(0) | benign(0.003) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CCDC113 | SNV | Missense_Mutation | rs146122026 | c.1082N>A | p.Arg361Gln | p.R361Q | Q9H0I3 | protein_coding | tolerated(0.74) | benign(0.001) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CCDC113 | SNV | Missense_Mutation | novel | c.1094N>T | p.Thr365Ile | p.T365I | Q9H0I3 | protein_coding | deleterious(0.01) | benign(0.383) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CCDC113 | SNV | Missense_Mutation | novel | c.479N>C | p.Lys160Thr | p.K160T | Q9H0I3 | protein_coding | tolerated(0.11) | benign(0.122) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |