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Gene: CBWD6 |
Gene summary for CBWD6 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CBWD6 | Gene ID | 644019 |
Gene name | COBW domain containing 6 | |
Gene Alias | CBWD7 | |
Cytomap | 9p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q4V339 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
644019 | CBWD6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.47e-02 | 1.16e-01 | 0.0155 |
644019 | CBWD6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.96e-12 | 4.96e-01 | -0.0811 |
644019 | CBWD6 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.06e-15 | 4.68e-01 | -0.1088 |
644019 | CBWD6 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.38e-29 | 6.53e-01 | -0.1954 |
644019 | CBWD6 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.38e-02 | 4.89e-01 | -0.2602 |
644019 | CBWD6 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.18e-04 | 3.08e-01 | -0.1526 |
644019 | CBWD6 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.12e-05 | 3.07e-01 | -0.1464 |
644019 | CBWD6 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.70e-03 | 2.37e-01 | -0.1001 |
644019 | CBWD6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.40e-13 | 5.42e-01 | -0.059 |
644019 | CBWD6 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.24e-03 | 2.50e-01 | -0.0842 |
644019 | CBWD6 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.87e-06 | 3.33e-01 | 0.096 |
644019 | CBWD6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.78e-02 | 2.17e-01 | 0.0674 |
644019 | CBWD6 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.28e-02 | 3.18e-01 | 0.0588 |
644019 | CBWD6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.85e-03 | -1.11e-01 | 0.294 |
644019 | CBWD6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.71e-02 | -1.11e-01 | 0.3859 |
644019 | CBWD6 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.13e-03 | -1.11e-01 | 0.3005 |
644019 | CBWD6 | LZE22D1 | Human | Esophagus | HGIN | 3.26e-02 | 1.63e-01 | 0.0595 |
644019 | CBWD6 | LZE24T | Human | Esophagus | ESCC | 2.14e-21 | 5.12e-01 | 0.0596 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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