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Gene: CBWD3 |
Gene summary for CBWD3 |
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Gene information | Species | Human | Gene symbol | CBWD3 | Gene ID | 445571 |
Gene name | COBW domain containing 3 | |
Gene Alias | bA561O23.1 | |
Cytomap | 9q21.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A0A6YYH9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
445571 | CBWD3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.59e-05 | 2.64e-01 | -0.1954 |
445571 | CBWD3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.80e-08 | 1.06e+00 | 0.3487 |
445571 | CBWD3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.98e-02 | 2.72e-01 | 0.281 |
445571 | CBWD3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.61e-07 | 3.30e-01 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CBWD3 | SNV | Missense_Mutation | c.457N>A | p.Asp153Asn | p.D153N | Q5JTY5 | protein_coding | deleterious(0.01) | possibly_damaging(0.521) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CBWD3 | SNV | Missense_Mutation | novel | c.1171G>T | p.Asp391Tyr | p.D391Y | Q5JTY5 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.838) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CBWD3 | SNV | Missense_Mutation | c.431N>A | p.Gly144Asp | p.G144D | Q5JTY5 | protein_coding | deleterious(0) | possibly_damaging(0.797) | TCGA-AG-3901-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CBWD3 | SNV | Missense_Mutation | novel | c.248N>T | p.Ala83Val | p.A83V | Q5JTY5 | protein_coding | tolerated(0.08) | benign(0.168) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CBWD3 | SNV | Missense_Mutation | novel | c.1174N>A | p.Gln392Lys | p.Q392K | Q5JTY5 | protein_coding | tolerated_low_confidence(0.06) | benign(0.001) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CBWD3 | SNV | Missense_Mutation | novel | c.614N>T | p.Thr205Ile | p.T205I | Q5JTY5 | protein_coding | tolerated(0.15) | benign(0.086) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CBWD3 | SNV | Missense_Mutation | novel | c.1067G>A | p.Arg356Gln | p.R356Q | Q5JTY5 | protein_coding | tolerated(0.16) | benign(0.127) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CBWD3 | SNV | Missense_Mutation | novel | c.1009N>T | p.Leu337Phe | p.L337F | Q5JTY5 | protein_coding | deleterious(0.02) | benign(0.209) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CBWD3 | SNV | Missense_Mutation | novel | c.642G>T | p.Lys214Asn | p.K214N | Q5JTY5 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
CBWD3 | SNV | Missense_Mutation | c.1030N>T | p.Pro344Ser | p.P344S | Q5JTY5 | protein_coding | tolerated(0.23) | benign(0.006) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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