Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CAVIN3

Gene summary for CAVIN3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CAVIN3

Gene ID

112464

Gene namecaveolae associated protein 3
Gene AliasHSRBC
Cytomap11p15.4
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

Q969G5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
112464CAVIN3male-WTAHumanThyroidPTC2.43e-038.01e-020.1037
112464CAVIN3ATC09HumanThyroidATC6.18e-031.75e-010.2871
112464CAVIN3ATC11HumanThyroidATC2.02e-169.77e-010.3386
112464CAVIN3ATC12HumanThyroidATC1.18e-861.71e+000.34
112464CAVIN3ATC13HumanThyroidATC1.87e-591.38e+000.34
112464CAVIN3ATC1HumanThyroidATC2.78e-042.20e-010.2878
112464CAVIN3ATC2HumanThyroidATC5.16e-322.52e+000.34
112464CAVIN3ATC3HumanThyroidATC9.91e-187.88e-010.338
112464CAVIN3ATC4HumanThyroidATC2.01e-982.01e+000.34
112464CAVIN3ATC5HumanThyroidATC3.84e-651.49e+000.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006091112ThyroidPTCgeneration of precursor metabolites and energy252/5968490/187238.24e-201.13e-17252
GO:0015980111ThyroidPTCenergy derivation by oxidation of organic compounds176/5968318/187232.67e-182.90e-16176
GO:003292219ThyroidPTCcircadian regulation of gene expression43/596868/187231.03e-072.05e-0643
GO:0030865110ThyroidPTCcortical cytoskeleton organization38/596861/187239.77e-071.46e-0538
GO:0043467110ThyroidPTCregulation of generation of precursor metabolites and energy68/5968130/187231.03e-061.52e-0568
GO:0048511111ThyroidPTCrhythmic process131/5968298/187237.06e-068.33e-05131
GO:0007623111ThyroidPTCcircadian rhythm96/5968210/187231.74e-051.82e-0496
GO:003086616ThyroidPTCcortical actin cytoskeleton organization25/596840/187236.51e-055.72e-0425
GO:00434918ThyroidPTCprotein kinase B signaling88/5968211/187231.59e-038.81e-0388
GO:00518969ThyroidPTCregulation of protein kinase B signaling74/5968185/187231.16e-024.58e-0274
GO:000609134ThyroidATCgeneration of precursor metabolites and energy256/6293490/187236.55e-187.69e-16256
GO:001598034ThyroidATCenergy derivation by oxidation of organic compounds177/6293318/187233.60e-162.92e-14177
GO:003086523ThyroidATCcortical cytoskeleton organization41/629361/187238.28e-081.43e-0641
GO:003292223ThyroidATCcircadian regulation of gene expression43/629368/187235.45e-077.79e-0643
GO:004851124ThyroidATCrhythmic process141/6293298/187235.58e-077.93e-06141
GO:003086617ThyroidATCcortical actin cytoskeleton organization28/629340/187232.77e-063.19e-0528
GO:004346726ThyroidATCregulation of generation of precursor metabolites and energy68/6293130/187238.19e-068.27e-0568
GO:000762325ThyroidATCcircadian rhythm100/6293210/187231.67e-051.54e-04100
GO:004349116ThyroidATCprotein kinase B signaling87/6293211/187231.20e-024.27e-0287
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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