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Gene: CAVIN2 |
Gene summary for CAVIN2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CAVIN2 | Gene ID | 8436 |
| Gene name | caveolae associated protein 2 | |
| Gene Alias | PS-p68 | |
| Cytomap | 2q32.3 | |
| Gene Type | protein-coding | GO ID | GO:0007009 | UniProtAcc | O95810 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8436 | CAVIN2 | LZE7T | Human | Esophagus | ESCC | 8.50e-22 | 1.73e+00 | 0.0667 |
| 8436 | CAVIN2 | LZE8T | Human | Esophagus | ESCC | 1.65e-04 | 2.12e-01 | 0.067 |
| 8436 | CAVIN2 | LZE24T | Human | Esophagus | ESCC | 5.74e-23 | 6.99e-01 | 0.0596 |
| 8436 | CAVIN2 | male-WTA | Human | Thyroid | PTC | 2.61e-10 | 1.98e-01 | 0.1037 |
| 8436 | CAVIN2 | nodule-WTA | Human | Thyroid | goiters | 1.25e-04 | 2.43e-01 | 0.0534 |
| 8436 | CAVIN2 | PTC01 | Human | Thyroid | PTC | 2.11e-25 | 5.42e-01 | 0.1899 |
| 8436 | CAVIN2 | PTC03 | Human | Thyroid | PTC | 2.61e-05 | 3.77e-01 | 0.1784 |
| 8436 | CAVIN2 | PTC04 | Human | Thyroid | PTC | 5.95e-07 | 2.78e-01 | 0.1927 |
| 8436 | CAVIN2 | PTC05 | Human | Thyroid | PTC | 9.52e-04 | 2.63e-01 | 0.2065 |
| 8436 | CAVIN2 | PTC06 | Human | Thyroid | PTC | 3.17e-19 | 7.59e-01 | 0.2057 |
| 8436 | CAVIN2 | PTC07 | Human | Thyroid | PTC | 3.04e-38 | 9.65e-01 | 0.2044 |
| 8436 | CAVIN2 | ATC11 | Human | Thyroid | ATC | 2.49e-06 | 2.03e+00 | 0.3386 |
| 8436 | CAVIN2 | ATC2 | Human | Thyroid | ATC | 5.35e-04 | 4.38e-01 | 0.34 |
| 8436 | CAVIN2 | ATC3 | Human | Thyroid | ATC | 6.22e-03 | 3.22e-01 | 0.338 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00973202 | Thyroid | PTC | plasma membrane tubulation | 13/5968 | 20/18723 | 2.37e-03 | 1.24e-02 | 13 |
| GO:009732011 | Thyroid | ATC | plasma membrane tubulation | 13/6293 | 20/18723 | 4.03e-03 | 1.73e-02 | 13 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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