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Gene: CASD1 |
Gene summary for CASD1 |
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Gene information | Species | Human | Gene symbol | CASD1 | Gene ID | 64921 |
Gene name | CAS1 domain containing 1 | |
Gene Alias | C7orf12 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q8WZ77 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64921 | CASD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.29e-13 | -5.67e-01 | 0.0155 |
64921 | CASD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.15e-06 | -5.00e-01 | -0.1808 |
64921 | CASD1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.39e-03 | -6.80e-01 | 0.0216 |
64921 | CASD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.57e-04 | -4.83e-01 | -0.0811 |
64921 | CASD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.90e-03 | -4.89e-01 | -0.1207 |
64921 | CASD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.11e-08 | -3.86e-01 | -0.1464 |
64921 | CASD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.82e-02 | -3.46e-01 | -0.1001 |
64921 | CASD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.77e-10 | -5.43e-01 | -0.059 |
64921 | CASD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.76e-13 | -5.92e-01 | 0.096 |
64921 | CASD1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.61e-03 | -6.32e-01 | 0.0528 |
64921 | CASD1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.15e-08 | -5.76e-01 | 0.0338 |
64921 | CASD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.26e-17 | -5.58e-01 | 0.0674 |
64921 | CASD1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.43e-03 | -5.10e-01 | 0.0588 |
64921 | CASD1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.24e-15 | -5.18e-01 | 0.294 |
64921 | CASD1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.26e-15 | -5.38e-01 | 0.3859 |
64921 | CASD1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.78e-04 | -5.85e-01 | 0.2585 |
64921 | CASD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.16e-16 | -5.55e-01 | 0.3005 |
64921 | CASD1 | F007 | Human | Colorectum | FAP | 2.47e-04 | -4.62e-01 | 0.1176 |
64921 | CASD1 | A002-C-010 | Human | Colorectum | FAP | 5.99e-04 | -2.83e-01 | 0.242 |
64921 | CASD1 | A001-C-207 | Human | Colorectum | FAP | 1.18e-02 | -3.15e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CASD1 | SNV | Missense_Mutation | novel | c.51N>A | p.Phe17Leu | p.F17L | Q96PB1 | protein_coding | tolerated(0.29) | benign(0.074) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
CASD1 | SNV | Missense_Mutation | novel | c.183G>T | p.Glu61Asp | p.E61D | Q96PB1 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CASD1 | SNV | Missense_Mutation | rs761691839 | c.1291N>G | p.Thr431Ala | p.T431A | Q96PB1 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-EW-A1PH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
CASD1 | SNV | Missense_Mutation | c.100N>T | p.Ala34Ser | p.A34S | Q96PB1 | protein_coding | tolerated(0.2) | benign(0) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CASD1 | SNV | Missense_Mutation | c.1615A>C | p.Ile539Leu | p.I539L | Q96PB1 | protein_coding | tolerated(0.51) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CASD1 | SNV | Missense_Mutation | novel | c.1872N>T | p.Gln624His | p.Q624H | Q96PB1 | protein_coding | tolerated(0.15) | probably_damaging(0.983) | TCGA-VS-AA62-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CASD1 | SNV | Missense_Mutation | rs780697479 | c.1486N>T | p.Arg496Cys | p.R496C | Q96PB1 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
CASD1 | SNV | Missense_Mutation | novel | c.965T>C | p.Leu322Ser | p.L322S | Q96PB1 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CASD1 | SNV | Missense_Mutation | c.1375N>T | p.His459Tyr | p.H459Y | Q96PB1 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CASD1 | SNV | Missense_Mutation | novel | c.1106A>C | p.Gln369Pro | p.Q369P | Q96PB1 | protein_coding | tolerated(0.19) | benign(0.266) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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