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Gene: CASC4 |
Gene summary for CASC4 |
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Gene information | Species | Human | Gene symbol | CASC4 | Gene ID | 113201 |
Gene name | golgi membrane protein 2 | |
Gene Alias | CASC4 | |
Cytomap | 15q15.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6P4E1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113201 | CASC4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.13e-39 | -9.00e-01 | 0.0155 |
113201 | CASC4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.65e-24 | -9.00e-01 | -0.1808 |
113201 | CASC4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.05e-06 | -9.00e-01 | 0.0216 |
113201 | CASC4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.53e-18 | -9.00e-01 | -0.0811 |
113201 | CASC4 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.10e-28 | -9.00e-01 | -0.1088 |
113201 | CASC4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.27e-41 | -9.00e-01 | -0.1954 |
113201 | CASC4 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.12e-04 | -9.00e-01 | -0.2602 |
113201 | CASC4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.82e-05 | -9.00e-01 | -0.2196 |
113201 | CASC4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.35e-19 | -9.00e-01 | -0.1207 |
113201 | CASC4 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.19e-15 | -9.00e-01 | -0.1526 |
113201 | CASC4 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.40e-59 | -9.00e-01 | -0.1464 |
113201 | CASC4 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.41e-57 | -9.00e-01 | -0.1001 |
113201 | CASC4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.39e-32 | -9.00e-01 | -0.059 |
113201 | CASC4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.16e-08 | -9.00e-01 | -0.1706 |
113201 | CASC4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.77e-09 | -9.00e-01 | -0.2061 |
113201 | CASC4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.05e-06 | -9.00e-01 | -0.1462 |
113201 | CASC4 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.08e-13 | -9.00e-01 | -0.0842 |
113201 | CASC4 | HTA11_9341_2000001011 | Human | Colorectum | SER | 9.12e-04 | -9.00e-01 | -0.00410000000000005 |
113201 | CASC4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.75e-11 | -9.00e-01 | -0.0179 |
113201 | CASC4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.18e-34 | -9.00e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CASC4 | SNV | Missense_Mutation | c.631C>G | p.Gln211Glu | p.Q211E | Q6P4E1 | protein_coding | tolerated(0.79) | benign(0.009) | TCGA-A8-A075-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | CR | |
CASC4 | SNV | Missense_Mutation | c.1037N>G | p.Lys346Arg | p.K346R | Q6P4E1 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-AC-A2FG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | CR | |
CASC4 | SNV | Missense_Mutation | novel | c.77N>C | p.Val26Ala | p.V26A | Q6P4E1 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CASC4 | SNV | Missense_Mutation | c.349N>A | p.Ser117Thr | p.S117T | Q6P4E1 | protein_coding | tolerated(0.57) | probably_damaging(0.961) | TCGA-E9-A1R7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | fareston | SD | |
CASC4 | SNV | Missense_Mutation | novel | c.56N>G | p.Val19Gly | p.V19G | Q6P4E1 | protein_coding | deleterious(0) | benign(0.073) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CASC4 | SNV | Missense_Mutation | novel | c.1212N>G | p.Asp404Glu | p.D404E | Q6P4E1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CASC4 | SNV | Missense_Mutation | c.582G>T | p.Glu194Asp | p.E194D | Q6P4E1 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CASC4 | SNV | Missense_Mutation | c.301N>A | p.Leu101Ile | p.L101I | Q6P4E1 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CASC4 | SNV | Missense_Mutation | novel | c.576G>T | p.Lys192Asn | p.K192N | Q6P4E1 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CASC4 | SNV | Missense_Mutation | c.525N>T | p.Gln175His | p.Q175H | Q6P4E1 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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