![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CARS1 |
Gene summary for CARS1 |
![]() |
Gene information | Species | Human | Gene symbol | CARS1 | Gene ID | 833 |
Gene name | cysteinyl-tRNA synthetase 1 | |
Gene Alias | CARS | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | P49589 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
833 | CARS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.23e-06 | 1.49e-01 | 0.0155 |
833 | CARS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.14e-15 | 4.55e-01 | -0.1808 |
833 | CARS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.43e-08 | 2.54e-01 | -0.0811 |
833 | CARS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.65e-10 | 2.42e-01 | -0.1088 |
833 | CARS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.18e-21 | 4.19e-01 | -0.1954 |
833 | CARS1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.42e-10 | 6.61e-01 | -0.2602 |
833 | CARS1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.76e-08 | 5.07e-01 | -0.2196 |
833 | CARS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.02e-14 | 4.28e-01 | -0.1207 |
833 | CARS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.46e-11 | 3.47e-01 | -0.1526 |
833 | CARS1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.02e-22 | 4.15e-01 | -0.1464 |
833 | CARS1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.66e-01 | -0.1001 |
833 | CARS1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.20e-22 | 5.44e-01 | -0.059 |
833 | CARS1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 2.63e-01 | -0.1706 |
833 | CARS1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.16e-07 | 2.80e-01 | -0.2061 |
833 | CARS1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.36e-01 | -0.1462 |
833 | CARS1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.43e-09 | 3.18e-01 | -0.0842 |
833 | CARS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.15e-09 | 2.33e-01 | 0.096 |
833 | CARS1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 2.05e-01 | 0.0528 |
833 | CARS1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.98e-03 | 1.87e-01 | -0.0177 |
833 | CARS1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.21e-02 | 2.38e-01 | 0.0171 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006418 | Colorectum | AD | tRNA aminoacylation for protein translation | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:0043039 | Colorectum | AD | tRNA aminoacylation | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0043038 | Colorectum | AD | amino acid activation | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:00064181 | Colorectum | SER | tRNA aminoacylation for protein translation | 17/2897 | 41/18723 | 5.75e-05 | 1.35e-03 | 17 |
GO:00430391 | Colorectum | SER | tRNA aminoacylation | 17/2897 | 44/18723 | 1.64e-04 | 3.12e-03 | 17 |
GO:00430381 | Colorectum | SER | amino acid activation | 17/2897 | 45/18723 | 2.25e-04 | 3.91e-03 | 17 |
GO:00065201 | Colorectum | SER | cellular amino acid metabolic process | 61/2897 | 284/18723 | 4.20e-03 | 3.41e-02 | 61 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |