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Gene: CARKD |
Gene summary for CARKD |
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Gene information | Species | Human | Gene symbol | CARKD | Gene ID | 55739 |
Gene name | NAD(P)HX dehydratase | |
Gene Alias | CARKD | |
Cytomap | 13q34 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IW45 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55739 | CARKD | P2T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.19e-01 | 0.1177 |
55739 | CARKD | P4T-E | Human | Esophagus | ESCC | 1.26e-16 | 3.16e-01 | 0.1323 |
55739 | CARKD | P8T-E | Human | Esophagus | ESCC | 2.56e-16 | 3.27e-01 | 0.0889 |
55739 | CARKD | P9T-E | Human | Esophagus | ESCC | 1.34e-08 | 2.21e-01 | 0.1131 |
55739 | CARKD | P10T-E | Human | Esophagus | ESCC | 2.27e-21 | 3.87e-01 | 0.116 |
55739 | CARKD | P11T-E | Human | Esophagus | ESCC | 6.74e-09 | 3.08e-01 | 0.1426 |
55739 | CARKD | P12T-E | Human | Esophagus | ESCC | 1.06e-41 | 6.62e-01 | 0.1122 |
55739 | CARKD | P15T-E | Human | Esophagus | ESCC | 2.31e-15 | 2.90e-01 | 0.1149 |
55739 | CARKD | P16T-E | Human | Esophagus | ESCC | 2.27e-21 | 3.79e-01 | 0.1153 |
55739 | CARKD | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 2.54e-01 | 0.1278 |
55739 | CARKD | P19T-E | Human | Esophagus | ESCC | 3.75e-07 | 4.34e-01 | 0.1662 |
55739 | CARKD | P20T-E | Human | Esophagus | ESCC | 2.16e-09 | 2.08e-01 | 0.1124 |
55739 | CARKD | P21T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.16e-01 | 0.1617 |
55739 | CARKD | P23T-E | Human | Esophagus | ESCC | 6.53e-09 | 2.14e-01 | 0.108 |
55739 | CARKD | P24T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.89e-01 | 0.1287 |
55739 | CARKD | P26T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.63e-01 | 0.1276 |
55739 | CARKD | P27T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.69e-01 | 0.1055 |
55739 | CARKD | P28T-E | Human | Esophagus | ESCC | 9.74e-22 | 3.88e-01 | 0.1149 |
55739 | CARKD | P30T-E | Human | Esophagus | ESCC | 9.17e-18 | 5.38e-01 | 0.137 |
55739 | CARKD | P31T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.34e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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