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Gene: CARD18 |
Gene summary for CARD18 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CARD18 | Gene ID | 59082 |
| Gene name | caspase recruitment domain family member 18 | |
| Gene Alias | ICEBERG | |
| Cytomap | 11q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | P57730 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 59082 | CARD18 | P1_S1_AK | Human | Skin | AK | 9.41e-05 | 1.31e-01 | -0.3399 |
| 59082 | CARD18 | P2_S3_AK | Human | Skin | AK | 1.90e-03 | 1.84e-01 | -0.3287 |
| 59082 | CARD18 | P3_S6_AK | Human | Skin | AK | 9.41e-05 | 2.21e-01 | -0.3256 |
| 59082 | CARD18 | P4_S8_cSCC | Human | Skin | cSCC | 3.04e-09 | 2.61e-01 | -0.3095 |
| 59082 | CARD18 | P2_cSCC | Human | Skin | cSCC | 1.18e-15 | 4.29e-01 | -0.024 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:005109826 | Skin | AK | regulation of binding | 74/1910 | 363/18723 | 4.40e-09 | 3.30e-07 | 74 |
| GO:005254727 | Skin | AK | regulation of peptidase activity | 88/1910 | 461/18723 | 4.65e-09 | 3.44e-07 | 88 |
| GO:004586127 | Skin | AK | negative regulation of proteolysis | 72/1910 | 351/18723 | 5.40e-09 | 3.90e-07 | 72 |
| GO:005254827 | Skin | AK | regulation of endopeptidase activity | 82/1910 | 432/18723 | 2.03e-08 | 1.18e-06 | 82 |
| GO:200011627 | Skin | AK | regulation of cysteine-type endopeptidase activity | 48/1910 | 235/18723 | 2.09e-06 | 6.01e-05 | 48 |
| GO:001046625 | Skin | AK | negative regulation of peptidase activity | 51/1910 | 262/18723 | 4.43e-06 | 1.07e-04 | 51 |
| GO:005134626 | Skin | AK | negative regulation of hydrolase activity | 67/1910 | 379/18723 | 5.22e-06 | 1.21e-04 | 67 |
| GO:001095120 | Skin | AK | negative regulation of endopeptidase activity | 49/1910 | 252/18723 | 6.98e-06 | 1.55e-04 | 49 |
| GO:200011724 | Skin | AK | negative regulation of cysteine-type endopeptidase activity | 23/1910 | 86/18723 | 1.13e-05 | 2.36e-04 | 23 |
| GO:004339324 | Skin | AK | regulation of protein binding | 36/1910 | 196/18723 | 3.52e-04 | 3.50e-03 | 36 |
| GO:005110024 | Skin | AK | negative regulation of binding | 29/1910 | 162/18723 | 1.89e-03 | 1.29e-02 | 29 |
| GO:005109827 | Skin | cSCC | regulation of binding | 152/4864 | 363/18723 | 2.21e-11 | 1.10e-09 | 152 |
| GO:005254728 | Skin | cSCC | regulation of peptidase activity | 177/4864 | 461/18723 | 2.21e-09 | 8.02e-08 | 177 |
| GO:005254828 | Skin | cSCC | regulation of endopeptidase activity | 165/4864 | 432/18723 | 1.18e-08 | 3.63e-07 | 165 |
| GO:005160419 | Skin | cSCC | protein maturation | 117/4864 | 294/18723 | 1.27e-07 | 2.93e-06 | 117 |
| GO:200011628 | Skin | cSCC | regulation of cysteine-type endopeptidase activity | 97/4864 | 235/18723 | 2.01e-07 | 4.34e-06 | 97 |
| GO:004339325 | Skin | cSCC | regulation of protein binding | 79/4864 | 196/18723 | 7.59e-06 | 1.04e-04 | 79 |
| GO:004586128 | Skin | cSCC | negative regulation of proteolysis | 128/4864 | 351/18723 | 7.95e-06 | 1.09e-04 | 128 |
| GO:2000117111 | Skin | cSCC | negative regulation of cysteine-type endopeptidase activity | 41/4864 | 86/18723 | 1.20e-05 | 1.53e-04 | 41 |
| GO:005110025 | Skin | cSCC | negative regulation of binding | 67/4864 | 162/18723 | 1.34e-05 | 1.68e-04 | 67 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CARD18 | SNV | Missense_Mutation | c.154G>A | p.Asp52Asn | p.D52N | P57730 | protein_coding | deleterious(0.03) | possibly_damaging(0.652) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| CARD18 | SNV | Missense_Mutation | c.71N>A | p.Ala24Asp | p.A24D | P57730 | protein_coding | deleterious(0.04) | benign(0.407) | TCGA-AA-3867-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
| CARD18 | SNV | Missense_Mutation | novel | c.70N>A | p.Ala24Thr | p.A24T | P57730 | protein_coding | deleterious(0.04) | benign(0.326) | TCGA-AA-3867-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
| CARD18 | SNV | Missense_Mutation | novel | c.226N>A | p.Leu76Ile | p.L76I | P57730 | protein_coding | tolerated(1) | benign(0.08) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| CARD18 | SNV | Missense_Mutation | c.36N>G | p.Ile12Met | p.I12M | P57730 | protein_coding | tolerated(0.14) | possibly_damaging(0.666) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| CARD18 | SNV | Missense_Mutation | novel | c.261N>A | p.Met87Ile | p.M87I | P57730 | protein_coding | deleterious(0.03) | benign(0.065) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| CARD18 | SNV | Missense_Mutation | novel | c.216N>G | p.Phe72Leu | p.F72L | P57730 | protein_coding | tolerated(1) | benign(0.247) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| CARD18 | SNV | Missense_Mutation | c.45N>G | p.His15Gln | p.H15Q | P57730 | protein_coding | tolerated(0.54) | benign(0.03) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| CARD18 | SNV | Missense_Mutation | c.232G>A | p.Glu78Lys | p.E78K | P57730 | protein_coding | tolerated(0.39) | benign(0.085) | TCGA-D1-A16J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| CARD18 | SNV | Missense_Mutation | c.215T>G | p.Phe72Cys | p.F72C | P57730 | protein_coding | tolerated(0.45) | benign(0.101) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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