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Gene: CAPNS2 |
Gene summary for CAPNS2 |
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Gene information | Species | Human | Gene symbol | CAPNS2 | Gene ID | 84290 |
Gene name | calpain small subunit 2 | |
Gene Alias | CSS2 | |
Cytomap | 16q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q96L46 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84290 | CAPNS2 | LZE4T | Human | Esophagus | ESCC | 1.90e-03 | 3.05e-01 | 0.0811 |
84290 | CAPNS2 | LZE8T | Human | Esophagus | ESCC | 2.44e-08 | 3.32e-01 | 0.067 |
84290 | CAPNS2 | LZE20T | Human | Esophagus | ESCC | 7.57e-09 | 3.53e-01 | 0.0662 |
84290 | CAPNS2 | LZE21D1 | Human | Esophagus | HGIN | 1.25e-04 | 1.53e+00 | 0.0632 |
84290 | CAPNS2 | LZE24T | Human | Esophagus | ESCC | 1.17e-22 | 1.07e+00 | 0.0596 |
84290 | CAPNS2 | LZE21T | Human | Esophagus | ESCC | 1.99e-05 | 7.15e-01 | 0.0655 |
84290 | CAPNS2 | P1T-E | Human | Esophagus | ESCC | 1.01e-10 | 8.86e-01 | 0.0875 |
84290 | CAPNS2 | P4T-E | Human | Esophagus | ESCC | 2.50e-15 | 5.61e-01 | 0.1323 |
84290 | CAPNS2 | P5T-E | Human | Esophagus | ESCC | 4.59e-18 | 5.08e-01 | 0.1327 |
84290 | CAPNS2 | P8T-E | Human | Esophagus | ESCC | 8.47e-10 | 3.41e-01 | 0.0889 |
84290 | CAPNS2 | P10T-E | Human | Esophagus | ESCC | 5.52e-40 | 8.62e-01 | 0.116 |
84290 | CAPNS2 | P12T-E | Human | Esophagus | ESCC | 1.40e-03 | 2.69e-01 | 0.1122 |
84290 | CAPNS2 | P15T-E | Human | Esophagus | ESCC | 1.25e-06 | 2.39e-01 | 0.1149 |
84290 | CAPNS2 | P16T-E | Human | Esophagus | ESCC | 1.98e-02 | -4.47e-02 | 0.1153 |
84290 | CAPNS2 | P22T-E | Human | Esophagus | ESCC | 7.82e-66 | 1.34e+00 | 0.1236 |
84290 | CAPNS2 | P23T-E | Human | Esophagus | ESCC | 1.89e-18 | 7.33e-01 | 0.108 |
84290 | CAPNS2 | P26T-E | Human | Esophagus | ESCC | 5.92e-52 | 1.38e+00 | 0.1276 |
84290 | CAPNS2 | P27T-E | Human | Esophagus | ESCC | 1.34e-18 | 4.63e-01 | 0.1055 |
84290 | CAPNS2 | P28T-E | Human | Esophagus | ESCC | 9.07e-24 | 6.22e-01 | 0.1149 |
84290 | CAPNS2 | P30T-E | Human | Esophagus | ESCC | 9.94e-21 | 1.04e+00 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPNS2 | SNV | Missense_Mutation | rs766790678 | c.239N>A | p.Arg80Gln | p.R80Q | Q96L46 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CAPNS2 | SNV | Missense_Mutation | c.544N>T | p.Gly182Cys | p.G182C | Q96L46 | protein_coding | deleterious(0.03) | probably_damaging(0.934) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
CAPNS2 | SNV | Missense_Mutation | rs766891009 | c.383N>C | p.Val128Ala | p.V128A | Q96L46 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAPNS2 | SNV | Missense_Mutation | rs540136871 | c.541G>A | p.Ala181Thr | p.A181T | Q96L46 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CAPNS2 | SNV | Missense_Mutation | c.150G>C | p.Glu50Asp | p.E50D | Q96L46 | protein_coding | tolerated(0.12) | possibly_damaging(0.883) | TCGA-D5-7000-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPNS2 | insertion | Frame_Shift_Ins | novel | c.707_708insA | p.Ser237ValfsTer68 | p.S237Vfs*68 | Q96L46 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
CAPNS2 | SNV | Missense_Mutation | c.612N>T | p.Met204Ile | p.M204I | Q96L46 | protein_coding | tolerated(0.7) | benign(0.019) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CAPNS2 | SNV | Missense_Mutation | c.503N>A | p.Ser168Tyr | p.S168Y | Q96L46 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CAPNS2 | SNV | Missense_Mutation | rs766790678 | c.239N>A | p.Arg80Gln | p.R80Q | Q96L46 | protein_coding | tolerated(1) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CAPNS2 | SNV | Missense_Mutation | c.476A>C | p.Lys159Thr | p.K159T | Q96L46 | protein_coding | deleterious(0.02) | benign(0.186) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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