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Gene: CAPN9 |
Gene summary for CAPN9 |
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Gene information | Species | Human | Gene symbol | CAPN9 | Gene ID | 10753 |
Gene name | calpain 9 | |
Gene Alias | GC36 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B4DNR4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10753 | CAPN9 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.42e-05 | 3.10e-01 | -0.1088 |
10753 | CAPN9 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.24e-03 | 3.41e-01 | -0.1207 |
10753 | CAPN9 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.21e-07 | 2.22e-01 | -0.1464 |
10753 | CAPN9 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.68e-04 | 2.00e-01 | -0.1001 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN9 | SNV | Missense_Mutation | rs779954945 | c.1343C>T | p.Thr448Met | p.T448M | O14815 | protein_coding | deleterious(0) | possibly_damaging(0.884) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CAPN9 | SNV | Missense_Mutation | c.730N>A | p.Ala244Thr | p.A244T | O14815 | protein_coding | tolerated(0.2) | probably_damaging(0.999) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPN9 | SNV | Missense_Mutation | rs145648359 | c.1033N>A | p.Ala345Thr | p.A345T | O14815 | protein_coding | tolerated(0.51) | benign(0) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN9 | SNV | Missense_Mutation | rs199898968 | c.1576N>G | p.Leu526Val | p.L526V | O14815 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
CAPN9 | SNV | Missense_Mutation | c.62N>G | p.Ile21Ser | p.I21S | O14815 | protein_coding | tolerated(0.65) | benign(0) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
CAPN9 | SNV | Missense_Mutation | c.710N>A | p.Arg237Lys | p.R237K | O14815 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
CAPN9 | insertion | Nonsense_Mutation | novel | c.667_668insAGAGCACATATATGTAAAATGCATATGAATAAAAGAGATGA | p.Ala223GlufsTer6 | p.A223Efs*6 | O14815 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CAPN9 | insertion | Nonsense_Mutation | novel | c.858_859insTAATTTCTTGTTAATTGCAATTCTACTTTACTTCCCAGATGT | p.Asn286_Gly287insTer | p.N286_G287ins* | O14815 | protein_coding | TCGA-A8-A07O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | CR | |||
CAPN9 | insertion | Frame_Shift_Ins | novel | c.2052_2053insGACTCAGGGCCTCTCTCCGCCCAGTGTGGGAACTCAGGGTCTCT | p.His685AspfsTer17 | p.H685Dfs*17 | O14815 | protein_coding | TCGA-A8-A082-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
CAPN9 | SNV | Missense_Mutation | rs778638122 | c.182C>T | p.Pro61Leu | p.P61L | O14815 | protein_coding | tolerated(0.11) | possibly_damaging(0.543) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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