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Gene: CAPN15 |
Gene summary for CAPN15 |
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Gene information | Species | Human | Gene symbol | CAPN15 | Gene ID | 6650 |
Gene name | calpain 15 | |
Gene Alias | OGIN | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | O75808 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6650 | CAPN15 | HCC1_Meng | Human | Liver | HCC | 1.28e-14 | 4.50e-03 | 0.0246 |
6650 | CAPN15 | HCC2_Meng | Human | Liver | HCC | 1.94e-09 | 9.11e-02 | 0.0107 |
6650 | CAPN15 | S014 | Human | Liver | HCC | 8.34e-17 | 5.54e-01 | 0.2254 |
6650 | CAPN15 | S015 | Human | Liver | HCC | 3.98e-16 | 6.35e-01 | 0.2375 |
6650 | CAPN15 | S016 | Human | Liver | HCC | 7.21e-20 | 6.44e-01 | 0.2243 |
6650 | CAPN15 | S027 | Human | Liver | HCC | 1.38e-11 | 7.34e-01 | 0.2446 |
6650 | CAPN15 | S028 | Human | Liver | HCC | 1.32e-22 | 6.67e-01 | 0.2503 |
6650 | CAPN15 | S029 | Human | Liver | HCC | 4.96e-14 | 5.38e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN15 | SNV | Missense_Mutation | c.1588N>G | p.Arg530Gly | p.R530G | O75808 | protein_coding | tolerated(0.98) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CAPN15 | SNV | Missense_Mutation | c.2945N>T | p.Trp982Leu | p.W982L | O75808 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-BH-A1FR-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CAPN15 | SNV | Missense_Mutation | rs369295076 | c.151G>A | p.Ala51Thr | p.A51T | O75808 | protein_coding | tolerated_low_confidence(0.36) | benign(0.356) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAPN15 | SNV | Missense_Mutation | novel | c.3007N>A | p.Asp1003Asn | p.D1003N | O75808 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CAPN15 | SNV | Missense_Mutation | rs79123767 | c.3235N>A | p.Gly1079Ser | p.G1079S | O75808 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN15 | SNV | Missense_Mutation | c.1090G>A | p.Gly364Ser | p.G364S | O75808 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPN15 | SNV | Missense_Mutation | c.3160N>A | p.Ala1054Thr | p.A1054T | O75808 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CAPN15 | SNV | Missense_Mutation | c.1589G>T | p.Arg530Met | p.R530M | O75808 | protein_coding | deleterious(0.04) | possibly_damaging(0.447) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPN15 | SNV | Missense_Mutation | rs748393081 | c.1465G>A | p.Val489Met | p.V489M | O75808 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CAPN15 | SNV | Missense_Mutation | c.1844C>T | p.Ala615Val | p.A615V | O75808 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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