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Gene: CAMTA2 |
Gene summary for CAMTA2 |
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Gene information | Species | Human | Gene symbol | CAMTA2 | Gene ID | 23125 |
Gene name | calmodulin binding transcription activator 2 | |
Gene Alias | CAMTA2 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O94983 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23125 | CAMTA2 | LZE4T | Human | Esophagus | ESCC | 6.20e-03 | 1.44e-01 | 0.0811 |
23125 | CAMTA2 | LZE7T | Human | Esophagus | ESCC | 1.78e-03 | 1.83e-01 | 0.0667 |
23125 | CAMTA2 | LZE24T | Human | Esophagus | ESCC | 4.40e-08 | 2.17e-01 | 0.0596 |
23125 | CAMTA2 | P4T-E | Human | Esophagus | ESCC | 6.42e-06 | 1.80e-01 | 0.1323 |
23125 | CAMTA2 | P5T-E | Human | Esophagus | ESCC | 4.06e-06 | 1.74e-01 | 0.1327 |
23125 | CAMTA2 | P8T-E | Human | Esophagus | ESCC | 1.36e-11 | 2.88e-01 | 0.0889 |
23125 | CAMTA2 | P9T-E | Human | Esophagus | ESCC | 2.98e-02 | 1.21e-01 | 0.1131 |
23125 | CAMTA2 | P10T-E | Human | Esophagus | ESCC | 5.73e-05 | 1.48e-01 | 0.116 |
23125 | CAMTA2 | P11T-E | Human | Esophagus | ESCC | 3.43e-06 | 4.78e-01 | 0.1426 |
23125 | CAMTA2 | P12T-E | Human | Esophagus | ESCC | 1.28e-04 | 1.12e-01 | 0.1122 |
23125 | CAMTA2 | P15T-E | Human | Esophagus | ESCC | 8.02e-04 | 6.86e-02 | 0.1149 |
23125 | CAMTA2 | P16T-E | Human | Esophagus | ESCC | 2.16e-05 | 2.07e-01 | 0.1153 |
23125 | CAMTA2 | P17T-E | Human | Esophagus | ESCC | 1.79e-03 | 2.21e-01 | 0.1278 |
23125 | CAMTA2 | P19T-E | Human | Esophagus | ESCC | 5.80e-07 | 5.50e-01 | 0.1662 |
23125 | CAMTA2 | P21T-E | Human | Esophagus | ESCC | 5.13e-34 | 6.40e-01 | 0.1617 |
23125 | CAMTA2 | P22T-E | Human | Esophagus | ESCC | 3.72e-12 | 1.85e-01 | 0.1236 |
23125 | CAMTA2 | P23T-E | Human | Esophagus | ESCC | 7.36e-03 | 9.29e-02 | 0.108 |
23125 | CAMTA2 | P24T-E | Human | Esophagus | ESCC | 5.13e-09 | 2.72e-01 | 0.1287 |
23125 | CAMTA2 | P27T-E | Human | Esophagus | ESCC | 1.41e-05 | 1.17e-01 | 0.1055 |
23125 | CAMTA2 | P28T-E | Human | Esophagus | ESCC | 4.36e-11 | 1.72e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMTA2 | SNV | Missense_Mutation | c.935N>T | p.Ser312Phe | p.S312F | O94983 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.982) | TCGA-A1-A0SK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CAMTA2 | SNV | Missense_Mutation | rs560446249 | c.2305N>C | p.Glu769Gln | p.E769Q | O94983 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CAMTA2 | SNV | Missense_Mutation | c.1796N>T | p.Ser599Leu | p.S599L | O94983 | protein_coding | deleterious(0.01) | possibly_damaging(0.709) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CAMTA2 | SNV | Missense_Mutation | c.1670N>G | p.Thr557Ser | p.T557S | O94983 | protein_coding | tolerated(0.5) | benign(0.007) | TCGA-BH-A0E9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
CAMTA2 | SNV | Missense_Mutation | c.3625G>A | p.Glu1209Lys | p.E1209K | O94983 | protein_coding | tolerated_low_confidence(0.06) | benign(0.001) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CAMTA2 | insertion | Nonsense_Mutation | novel | c.1516_1517insTTCATTAACAGAAATTTGGAAATTACACAAAAGCACAAAATA | p.Gly506delinsValHisTerGlnLysPheGlyAsnTyrThrLysAlaGlnAsnArg | p.G506delinsVH*QKFGNYTKAQNR | O94983 | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CAMTA2 | insertion | Nonsense_Mutation | novel | c.2988_2989insAGCTGACCTGGATTGCACTTAAGGTATTAGGCATGAGCT | p.Thr996_Gly997insSerTerProGlyLeuHisLeuArgTyrTerAlaTerAla | p.T996_G997insS*PGLHLRY*A*A | O94983 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CAMTA2 | insertion | In_Frame_Ins | novel | c.1660_1661insGACCGAAGCCGCCGAGCA | p.Ala554delinsGlyProLysProProSerThr | p.A554delinsGPKPPST | O94983 | protein_coding | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CAMTA2 | insertion | In_Frame_Ins | novel | c.2006_2007insTATCCTCCTCCTGACAGGACTGGA | p.Leu668_Glu669insAspIleLeuLeuLeuThrGlyLeu | p.L668_E669insDILLLTGL | O94983 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
CAMTA2 | SNV | Missense_Mutation | novel | c.853N>G | p.Thr285Ala | p.T285A | O94983 | protein_coding | tolerated_low_confidence(0.37) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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