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Gene: CAMK4 |
Gene summary for CAMK4 |
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Gene information | Species | Human | Gene symbol | CAMK4 | Gene ID | 814 |
Gene name | calcium/calmodulin dependent protein kinase IV | |
Gene Alias | CaMK IV | |
Cytomap | 5q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001773 | UniProtAcc | Q16566 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
814 | CAMK4 | HCC1 | Human | Liver | HCC | 7.22e-07 | 1.52e+00 | 0.5336 |
814 | CAMK4 | HCC2 | Human | Liver | HCC | 1.99e-14 | 1.17e+00 | 0.5341 |
814 | CAMK4 | HCC5 | Human | Liver | HCC | 6.27e-22 | 1.77e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:003009922 | Liver | HCC | myeloid cell differentiation | 200/7958 | 381/18723 | 4.64e-05 | 4.49e-04 | 200 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
GO:00467775 | Liver | HCC | protein autophosphorylation | 123/7958 | 227/18723 | 2.40e-04 | 1.80e-03 | 123 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0472210 | Liver | HCC | Neurotrophin signaling pathway | 74/4020 | 119/8465 | 8.27e-04 | 3.26e-03 | 1.81e-03 | 74 |
hsa052142 | Liver | HCC | Glioma | 47/4020 | 75/8465 | 5.67e-03 | 1.62e-02 | 9.02e-03 | 47 |
hsa0472211 | Liver | HCC | Neurotrophin signaling pathway | 74/4020 | 119/8465 | 8.27e-04 | 3.26e-03 | 1.81e-03 | 74 |
hsa0521411 | Liver | HCC | Glioma | 47/4020 | 75/8465 | 5.67e-03 | 1.62e-02 | 9.02e-03 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMK4 | SNV | Missense_Mutation | novel | c.1367G>T | p.Ser456Ile | p.S456I | Q16566 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
CAMK4 | SNV | Missense_Mutation | novel | c.661N>C | p.Glu221Gln | p.E221Q | Q16566 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
CAMK4 | SNV | Missense_Mutation | c.236N>C | p.Lys79Thr | p.K79T | Q16566 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | tamoxiphen | SD | |
CAMK4 | SNV | Missense_Mutation | c.382N>C | p.Asp128His | p.D128H | Q16566 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CAMK4 | SNV | Missense_Mutation | novel | c.809C>T | p.Ser270Phe | p.S270F | Q16566 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAMK4 | SNV | Missense_Mutation | c.715G>C | p.Glu239Gln | p.E239Q | Q16566 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CAMK4 | SNV | Missense_Mutation | c.838N>G | p.Leu280Val | p.L280V | Q16566 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CAMK4 | SNV | Missense_Mutation | c.277C>A | p.Leu93Ile | p.L93I | Q16566 | protein_coding | deleterious(0) | probably_damaging(0.933) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
CAMK4 | SNV | Missense_Mutation | c.237A>C | p.Lys79Asn | p.K79N | Q16566 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAMK4 | SNV | Missense_Mutation | c.803A>G | p.Glu268Gly | p.E268G | Q16566 | protein_coding | deleterious(0) | benign(0.257) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
814 | CAMK4 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | ESTRADIOL BENZOATE | 11588616 |
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