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Gene: CADPS2 |
Gene summary for CADPS2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CADPS2 | Gene ID | 93664 |
| Gene name | calcium dependent secretion activator 2 | |
| Gene Alias | CAPS2 | |
| Cytomap | 7q31.32 | |
| Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q86UW7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 93664 | CADPS2 | CCI_3 | Human | Cervix | CC | 1.51e-11 | 8.69e-01 | 0.516 |
| 93664 | CADPS2 | H2 | Human | Cervix | HSIL_HPV | 1.04e-05 | 2.71e-01 | 0.0632 |
| 93664 | CADPS2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.15e-16 | -6.04e-01 | 0.0155 |
| 93664 | CADPS2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.09e-05 | -5.45e-01 | -0.1808 |
| 93664 | CADPS2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.14e-06 | -5.19e-01 | -0.1207 |
| 93664 | CADPS2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.06e-03 | -3.89e-01 | -0.1464 |
| 93664 | CADPS2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.02e-06 | -4.68e-01 | -0.1001 |
| 93664 | CADPS2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.47e-05 | -7.94e-01 | -0.2061 |
| 93664 | CADPS2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.06e-02 | -5.82e-01 | -0.0179 |
| 93664 | CADPS2 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.39e-08 | -4.74e-01 | 0.096 |
| 93664 | CADPS2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.09e-03 | -6.43e-01 | 0.0528 |
| 93664 | CADPS2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.77e-05 | -5.15e-01 | 0.0338 |
| 93664 | CADPS2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.02e-07 | -4.10e-01 | 0.0674 |
| 93664 | CADPS2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.35e-02 | -3.38e-01 | 0.3859 |
| 93664 | CADPS2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.49e-09 | -7.90e-01 | 0.2585 |
| 93664 | CADPS2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.02e-31 | -7.52e-01 | 0.3005 |
| 93664 | CADPS2 | A015-C-203 | Human | Colorectum | FAP | 3.70e-31 | -6.12e-01 | -0.1294 |
| 93664 | CADPS2 | A015-C-204 | Human | Colorectum | FAP | 4.43e-05 | -4.01e-01 | -0.0228 |
| 93664 | CADPS2 | A014-C-040 | Human | Colorectum | FAP | 5.91e-03 | -4.35e-01 | -0.1184 |
| 93664 | CADPS2 | A002-C-201 | Human | Colorectum | FAP | 7.12e-10 | -3.56e-01 | 0.0324 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00171574 | Cervix | CC | regulation of exocytosis | 39/2311 | 202/18723 | 2.90e-03 | 1.93e-02 | 39 |
| GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
| GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
| GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
| GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
| GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
| GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
| GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
| GO:00459211 | Colorectum | SER | positive regulation of exocytosis | 25/2897 | 86/18723 | 9.88e-04 | 1.17e-02 | 25 |
| GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
| GO:00510471 | Colorectum | SER | positive regulation of secretion | 65/2897 | 310/18723 | 5.71e-03 | 4.19e-02 | 65 |
| GO:00171571 | Colorectum | SER | regulation of exocytosis | 45/2897 | 202/18723 | 6.46e-03 | 4.63e-02 | 45 |
| GO:19035321 | Colorectum | MSS | positive regulation of secretion by cell | 74/3467 | 282/18723 | 7.93e-04 | 8.36e-03 | 74 |
| GO:00510472 | Colorectum | MSS | positive regulation of secretion | 80/3467 | 310/18723 | 8.55e-04 | 8.75e-03 | 80 |
| GO:00990031 | Colorectum | MSS | vesicle-mediated transport in synapse | 54/3467 | 200/18723 | 1.94e-03 | 1.67e-02 | 54 |
| GO:00459212 | Colorectum | MSS | positive regulation of exocytosis | 27/3467 | 86/18723 | 2.76e-03 | 2.17e-02 | 27 |
| GO:0099504 | Colorectum | MSS | synaptic vesicle cycle | 48/3467 | 181/18723 | 4.85e-03 | 3.39e-02 | 48 |
| GO:00990032 | Colorectum | FAP | vesicle-mediated transport in synapse | 51/2622 | 200/18723 | 1.09e-05 | 3.08e-04 | 51 |
| GO:00995041 | Colorectum | FAP | synaptic vesicle cycle | 45/2622 | 181/18723 | 6.73e-05 | 1.28e-03 | 45 |
| GO:0023061 | Colorectum | FAP | signal release | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CADPS2 | SNV | Missense_Mutation | novel | c.582N>C | p.Leu194Phe | p.L194F | Q86UW7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
| CADPS2 | SNV | Missense_Mutation | novel | c.676N>A | p.Leu226Ile | p.L226I | Q86UW7 | protein_coding | tolerated(0.42) | benign(0.388) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
| CADPS2 | SNV | Missense_Mutation | c.2339N>T | p.Ser780Leu | p.S780L | Q86UW7 | protein_coding | deleterious(0.03) | possibly_damaging(0.454) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CADPS2 | SNV | Missense_Mutation | novel | c.2371G>T | p.Ala791Ser | p.A791S | Q86UW7 | protein_coding | tolerated(0.35) | benign(0.15) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
| CADPS2 | SNV | Missense_Mutation | novel | c.3880N>A | p.Glu1294Lys | p.E1294K | Q86UW7 | protein_coding | tolerated_low_confidence(0.06) | benign(0.067) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
| CADPS2 | SNV | Missense_Mutation | novel | c.1039N>C | p.Asp347His | p.D347H | Q86UW7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CADPS2 | SNV | Missense_Mutation | novel | c.1151G>A | p.Arg384Gln | p.R384Q | Q86UW7 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CADPS2 | SNV | Missense_Mutation | c.1522N>T | p.Arg508Cys | p.R508C | Q86UW7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A0AV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
| CADPS2 | SNV | Missense_Mutation | c.1885G>C | p.Gly629Arg | p.G629R | Q86UW7 | protein_coding | deleterious(0) | possibly_damaging(0.67) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CADPS2 | SNV | Missense_Mutation | c.769N>T | p.Leu257Phe | p.L257F | Q86UW7 | protein_coding | deleterious(0) | possibly_damaging(0.476) | TCGA-E2-A14P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | trastuzumab | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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