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Gene: CAD |
Gene summary for CAD |
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Gene information | Species | Human | Gene symbol | CAD | Gene ID | 790 |
Gene name | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | |
Gene Alias | CDG1Z | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | F8VPD4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
790 | CAD | LZE4T | Human | Esophagus | ESCC | 5.13e-03 | 8.84e-02 | 0.0811 |
790 | CAD | LZE24T | Human | Esophagus | ESCC | 4.08e-03 | 5.93e-02 | 0.0596 |
790 | CAD | P1T-E | Human | Esophagus | ESCC | 1.43e-04 | 2.09e-01 | 0.0875 |
790 | CAD | P2T-E | Human | Esophagus | ESCC | 1.69e-08 | 2.10e-01 | 0.1177 |
790 | CAD | P4T-E | Human | Esophagus | ESCC | 6.37e-12 | 1.64e-01 | 0.1323 |
790 | CAD | P5T-E | Human | Esophagus | ESCC | 2.65e-04 | 1.24e-01 | 0.1327 |
790 | CAD | P8T-E | Human | Esophagus | ESCC | 1.26e-04 | 1.23e-01 | 0.0889 |
790 | CAD | P9T-E | Human | Esophagus | ESCC | 1.02e-03 | 9.63e-02 | 0.1131 |
790 | CAD | P10T-E | Human | Esophagus | ESCC | 1.67e-18 | 3.53e-01 | 0.116 |
790 | CAD | P11T-E | Human | Esophagus | ESCC | 2.15e-04 | 2.19e-01 | 0.1426 |
790 | CAD | P12T-E | Human | Esophagus | ESCC | 1.30e-07 | 1.83e-01 | 0.1122 |
790 | CAD | P15T-E | Human | Esophagus | ESCC | 8.99e-16 | 3.04e-01 | 0.1149 |
790 | CAD | P16T-E | Human | Esophagus | ESCC | 9.60e-09 | 1.84e-01 | 0.1153 |
790 | CAD | P17T-E | Human | Esophagus | ESCC | 7.98e-04 | 2.21e-01 | 0.1278 |
790 | CAD | P19T-E | Human | Esophagus | ESCC | 5.38e-03 | 4.59e-01 | 0.1662 |
790 | CAD | P20T-E | Human | Esophagus | ESCC | 1.92e-07 | 1.58e-01 | 0.1124 |
790 | CAD | P21T-E | Human | Esophagus | ESCC | 2.72e-13 | 2.49e-01 | 0.1617 |
790 | CAD | P22T-E | Human | Esophagus | ESCC | 8.77e-18 | 2.36e-01 | 0.1236 |
790 | CAD | P23T-E | Human | Esophagus | ESCC | 2.04e-05 | 1.24e-01 | 0.108 |
790 | CAD | P24T-E | Human | Esophagus | ESCC | 1.61e-05 | 1.63e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00159808 | Breast | Precancer | energy derivation by oxidation of organic compounds | 70/1080 | 318/18723 | 8.33e-23 | 6.37e-20 | 70 |
GO:00092667 | Breast | Precancer | response to temperature stimulus | 27/1080 | 178/18723 | 3.85e-06 | 1.21e-04 | 27 |
GO:00192164 | Breast | Precancer | regulation of lipid metabolic process | 34/1080 | 331/18723 | 8.14e-04 | 9.55e-03 | 34 |
GO:00463946 | Breast | Precancer | carboxylic acid biosynthetic process | 32/1080 | 314/18723 | 1.30e-03 | 1.38e-02 | 32 |
GO:00723304 | Breast | Precancer | monocarboxylic acid biosynthetic process | 24/1080 | 214/18723 | 1.41e-03 | 1.48e-02 | 24 |
GO:00160536 | Breast | Precancer | organic acid biosynthetic process | 32/1080 | 316/18723 | 1.44e-03 | 1.50e-02 | 32 |
GO:00094097 | Breast | Precancer | response to cold | 9/1080 | 49/18723 | 1.74e-03 | 1.74e-02 | 9 |
GO:00066335 | Breast | Precancer | fatty acid biosynthetic process | 19/1080 | 163/18723 | 2.74e-03 | 2.42e-02 | 19 |
GO:00620126 | Breast | Precancer | regulation of small molecule metabolic process | 32/1080 | 334/18723 | 3.45e-03 | 2.87e-02 | 32 |
GO:00423044 | Breast | Precancer | regulation of fatty acid biosynthetic process | 8/1080 | 49/18723 | 6.53e-03 | 4.51e-02 | 8 |
GO:000609113 | Breast | IDC | generation of precursor metabolites and energy | 103/1434 | 490/18723 | 1.53e-21 | 1.74e-18 | 103 |
GO:001598013 | Breast | IDC | energy derivation by oxidation of organic compounds | 73/1434 | 318/18723 | 8.70e-18 | 3.80e-15 | 73 |
GO:000926612 | Breast | IDC | response to temperature stimulus | 34/1434 | 178/18723 | 5.88e-07 | 2.83e-05 | 34 |
GO:000940912 | Breast | IDC | response to cold | 13/1434 | 49/18723 | 5.70e-05 | 1.20e-03 | 13 |
GO:001921612 | Breast | IDC | regulation of lipid metabolic process | 45/1434 | 331/18723 | 1.21e-04 | 2.24e-03 | 45 |
GO:00192184 | Breast | IDC | regulation of steroid metabolic process | 18/1434 | 100/18723 | 5.40e-04 | 6.96e-03 | 18 |
GO:00468904 | Breast | IDC | regulation of lipid biosynthetic process | 26/1434 | 171/18723 | 5.92e-04 | 7.50e-03 | 26 |
GO:007233012 | Breast | IDC | monocarboxylic acid biosynthetic process | 29/1434 | 214/18723 | 1.91e-03 | 1.83e-02 | 29 |
GO:001605313 | Breast | IDC | organic acid biosynthetic process | 39/1434 | 316/18723 | 2.13e-03 | 1.99e-02 | 39 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Breast | DCIS |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Breast | IDC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Cervix | Precancer |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | ADJ |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | CRC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | FAP |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | ADJ |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | AEH |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | EEC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | Healthy |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Esophagus | ADJ |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Esophagus | ESCC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | GC | ADJ |
CADM1 | CADM1 | CADM1_CADM1 | CADM | GC | GC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | GC | Precancer |
CADM3 | CADM3 | CADM3_CADM3 | CADM | GC | Precancer |
CADM3 | CADM3 | CADM3_CADM3 | CADM | HNSCC | ADJ |
CADM3 | CADM3 | CADM3_CADM3 | CADM | HNSCC | Healthy |
CADM1 | CADM1 | CADM1_CADM1 | CADM | HNSCC | OSCC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | HNSCC | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAD | SNV | Missense_Mutation | c.2277G>A | p.Met759Ile | p.M759I | P27708 | protein_coding | deleterious(0) | benign(0.03) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
CAD | SNV | Missense_Mutation | novel | c.6202N>C | p.Gly2068Arg | p.G2068R | P27708 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
CAD | SNV | Missense_Mutation | novel | c.6203N>T | p.Gly2068Val | p.G2068V | P27708 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
CAD | SNV | Missense_Mutation | c.6149N>A | p.Gly2050Glu | p.G2050E | P27708 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A2-A0YD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
CAD | SNV | Missense_Mutation | rs182811252 | c.5863N>T | p.Arg1955Trp | p.R1955W | P27708 | protein_coding | deleterious(0.02) | probably_damaging(0.949) | TCGA-A2-A1FX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
CAD | SNV | Missense_Mutation | rs367846045 | c.6367N>A | p.Gly2123Ser | p.G2123S | P27708 | protein_coding | deleterious(0.03) | probably_damaging(0.94) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAD | SNV | Missense_Mutation | c.1333N>T | p.Gly445Trp | p.G445W | P27708 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |
CAD | SNV | Missense_Mutation | c.2977N>A | p.Glu993Lys | p.E993K | P27708 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CAD | SNV | Missense_Mutation | novel | c.2888N>A | p.Arg963Gln | p.R963Q | P27708 | protein_coding | deleterious(0) | possibly_damaging(0.738) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAD | SNV | Missense_Mutation | c.1493N>T | p.Gly498Val | p.G498V | P27708 | protein_coding | deleterious(0) | benign(0.113) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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