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Gene: CACNA1E |
Gene summary for CACNA1E |
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Gene information | Species | Human | Gene symbol | CACNA1E | Gene ID | 777 |
Gene name | calcium voltage-gated channel subunit alpha1 E | |
Gene Alias | BII | |
Cytomap | 1q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q15878 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
777 | CACNA1E | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.55e-90 | 1.59e+00 | 0.0155 |
777 | CACNA1E | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.09e-47 | 1.28e+00 | -0.1808 |
777 | CACNA1E | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.52e-24 | 1.24e+00 | 0.0216 |
777 | CACNA1E | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.71e-55 | 1.63e+00 | -0.0811 |
777 | CACNA1E | HTA11_78_2000001011 | Human | Colorectum | AD | 2.61e-30 | 8.27e-01 | -0.1088 |
777 | CACNA1E | HTA11_347_2000001011 | Human | Colorectum | AD | 3.30e-111 | 1.81e+00 | -0.1954 |
777 | CACNA1E | HTA11_411_2000001011 | Human | Colorectum | SER | 1.58e-29 | 1.93e+00 | -0.2602 |
777 | CACNA1E | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.99e-12 | 9.89e-01 | -0.2196 |
777 | CACNA1E | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.05e-55 | 1.44e+00 | -0.1207 |
777 | CACNA1E | HTA11_83_2000001011 | Human | Colorectum | SER | 2.99e-32 | 1.21e+00 | -0.1526 |
777 | CACNA1E | HTA11_696_2000001011 | Human | Colorectum | AD | 3.59e-68 | 1.56e+00 | -0.1464 |
777 | CACNA1E | HTA11_866_2000001011 | Human | Colorectum | AD | 6.98e-38 | 7.66e-01 | -0.1001 |
777 | CACNA1E | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.81e-49 | 9.99e-01 | -0.059 |
777 | CACNA1E | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.03e-38 | 2.11e+00 | -0.1706 |
777 | CACNA1E | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.87e-52 | 2.20e+00 | -0.2061 |
777 | CACNA1E | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.34e-38 | 2.94e+00 | -0.1462 |
777 | CACNA1E | HTA11_546_2000001011 | Human | Colorectum | AD | 6.35e-47 | 1.71e+00 | -0.0842 |
777 | CACNA1E | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.28e-04 | 2.59e-01 | -0.0179 |
777 | CACNA1E | HTA11_866_3004761011 | Human | Colorectum | AD | 4.90e-06 | 1.89e-01 | 0.096 |
777 | CACNA1E | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.99e-02 | 2.97e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CACNA1E | SNV | Missense_Mutation | novel | c.6047N>A | p.Ser2016Tyr | p.S2016Y | Q15878 | protein_coding | deleterious(0.01) | probably_damaging(0.921) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
CACNA1E | SNV | Missense_Mutation | rs770435124 | c.4186N>T | p.Arg1396Cys | p.R1396C | Q15878 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0EW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
CACNA1E | SNV | Missense_Mutation | novel | c.4491N>A | p.Met1497Ile | p.M1497I | Q15878 | protein_coding | deleterious(0.02) | benign(0.118) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CACNA1E | SNV | Missense_Mutation | novel | c.6374G>T | p.Gly2125Val | p.G2125V | Q15878 | protein_coding | deleterious(0.01) | possibly_damaging(0.454) | TCGA-A7-A4SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CACNA1E | SNV | Missense_Mutation | c.439G>T | p.Gly147Trp | p.G147W | Q15878 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | |
CACNA1E | SNV | Missense_Mutation | c.2482C>T | p.Arg828Trp | p.R828W | Q15878 | protein_coding | deleterious(0.01) | possibly_damaging(0.585) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CACNA1E | SNV | Missense_Mutation | c.5064G>T | p.Gln1688His | p.Q1688H | Q15878 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CACNA1E | SNV | Missense_Mutation | c.6928G>C | p.Asp2310His | p.D2310H | Q15878 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CACNA1E | SNV | Missense_Mutation | novel | c.1769G>A | p.Arg590Gln | p.R590Q | Q15878 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-AC-A62X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CACNA1E | SNV | Missense_Mutation | c.1306N>C | p.Ser436Pro | p.S436P | Q15878 | protein_coding | tolerated(0.09) | benign(0.226) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | modulator | CHEMBL1059 | PREGABALIN | |
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | fentanyl | FENTANYL | ||
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | blocker | CHEMBL1200382 | BEPRIDIL HYDROCHLORIDE | |
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | modulator | CHEMBL2103836 | IMAGABALIN | |
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | modulator | CHEMBL1628502 | GABAPENTIN ENACARBIL | |
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | modulator | CHEMBL593430 | ATAGABALIN | |
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | modulator | CHEMBL940 | GABAPENTIN | |
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | blocker | 53801055 | ||
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | inhibitor | 178101132 | ||
777 | CACNA1E | DRUGGABLE GENOME, ION CHANNEL | blocker | 135652732 |
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