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Gene: C9orf66 |
Gene summary for C9ORF66 |
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Gene information | Species | Human | Gene symbol | C9orf66 | Gene ID | 157983 |
Gene name | DOCK8 antisense RNA 1 | |
Gene Alias | C9orf66 | |
Cytomap | 9p24.3 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
157983 | C9orf66 | HCC1_Meng | Human | Liver | HCC | 2.33e-07 | 1.65e-02 | 0.0246 |
157983 | C9orf66 | HCC1 | Human | Liver | HCC | 3.60e-07 | 9.49e-01 | 0.5336 |
157983 | C9orf66 | HCC2 | Human | Liver | HCC | 5.53e-20 | 1.59e+00 | 0.5341 |
157983 | C9orf66 | HCC5 | Human | Liver | HCC | 1.21e-07 | 7.32e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C9orf66 | insertion | In_Frame_Ins | novel | c.842_843insTTGGACAGTGCCAGTCCAATACAACCT | p.Glu281delinsAspTrpThrValProValGlnTyrAsnLeu | p.E281delinsDWTVPVQYNL | Q5T8R8 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
C9orf66 | SNV | Missense_Mutation | c.776N>A | p.Arg259His | p.R259H | Q5T8R8 | protein_coding | tolerated_low_confidence(0.07) | benign(0.094) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C9orf66 | SNV | Missense_Mutation | c.776N>A | p.Arg259His | p.R259H | Q5T8R8 | protein_coding | tolerated_low_confidence(0.07) | benign(0.094) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C9orf66 | SNV | Missense_Mutation | c.580N>T | p.Pro194Ser | p.P194S | Q5T8R8 | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.58) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C9orf66 | SNV | Missense_Mutation | novel | c.854N>T | p.Ala285Val | p.A285V | Q5T8R8 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
C9orf66 | SNV | Missense_Mutation | novel | c.869N>C | p.Asn290Thr | p.N290T | Q5T8R8 | protein_coding | deleterious_low_confidence(0.02) | benign(0.015) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C9orf66 | SNV | Missense_Mutation | novel | c.487N>G | p.Arg163Gly | p.R163G | Q5T8R8 | protein_coding | tolerated_low_confidence(0.12) | benign(0.023) | TCGA-BG-A0MO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C9orf66 | SNV | Missense_Mutation | novel | c.485N>A | p.Arg162His | p.R162H | Q5T8R8 | protein_coding | tolerated_low_confidence(0.14) | possibly_damaging(0.649) | TCGA-BG-A0MO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C9orf66 | SNV | Missense_Mutation | c.802N>A | p.Glu268Lys | p.E268K | Q5T8R8 | protein_coding | tolerated_low_confidence(0.18) | benign(0.05) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C9orf66 | insertion | Frame_Shift_Ins | novel | c.110_111insG | p.Arg38LysfsTer88 | p.R38Kfs*88 | Q5T8R8 | protein_coding | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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