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Gene: C9orf152 |
Gene summary for C9ORF152 |
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Gene information | Species | Human | Gene symbol | C9orf152 | Gene ID | 401546 |
Gene name | chromosome 9 open reading frame 152 | |
Gene Alias | bA470J20.2 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A8K2L3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401546 | C9orf152 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.08e-04 | 1.87e-01 | 0.0155 |
401546 | C9orf152 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.26e-04 | 4.07e-01 | -0.0811 |
401546 | C9orf152 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.23e-15 | 5.70e-01 | -0.1088 |
401546 | C9orf152 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.31e-19 | 5.63e-01 | -0.1954 |
401546 | C9orf152 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.15e-04 | 2.17e-01 | 0.096 |
401546 | C9orf152 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.73e-04 | 6.23e-01 | 0.0171 |
401546 | C9orf152 | HTA11_7469_2000001011 | Human | Colorectum | AD | 4.38e-05 | 5.80e-01 | -0.0124 |
401546 | C9orf152 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.37e-07 | 3.51e-01 | 0.294 |
401546 | C9orf152 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.79e-02 | 2.28e-01 | 0.281 |
401546 | C9orf152 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.46e-02 | 2.64e-01 | 0.3859 |
401546 | C9orf152 | F034 | Human | Colorectum | FAP | 3.85e-03 | -9.16e-02 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C9orf152 | SNV | Missense_Mutation | novel | c.56N>T | p.Ser19Phe | p.S19F | Q5JTZ5 | protein_coding | deleterious(0) | possibly_damaging(0.773) | TCGA-DG-A2KJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
C9orf152 | SNV | Missense_Mutation | c.221N>T | p.Ser74Leu | p.S74L | Q5JTZ5 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C9orf152 | SNV | Missense_Mutation | novel | c.553A>G | p.Thr185Ala | p.T185A | Q5JTZ5 | protein_coding | tolerated(0.34) | benign(0.006) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C9orf152 | SNV | Missense_Mutation | rs780345431 | c.356N>T | p.Thr119Met | p.T119M | Q5JTZ5 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
C9orf152 | SNV | Missense_Mutation | novel | c.565N>A | p.Ala189Thr | p.A189T | Q5JTZ5 | protein_coding | tolerated(0.17) | benign(0.067) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C9orf152 | SNV | Missense_Mutation | novel | c.455N>A | p.Pro152His | p.P152H | Q5JTZ5 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C9orf152 | SNV | Missense_Mutation | novel | c.164N>T | p.Thr55Ile | p.T55I | Q5JTZ5 | protein_coding | tolerated(0.2) | possibly_damaging(0.548) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C9orf152 | SNV | Missense_Mutation | c.221C>T | p.Ser74Leu | p.S74L | Q5JTZ5 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
C9orf152 | SNV | Missense_Mutation | novel | c.692N>A | p.Arg231Gln | p.R231Q | Q5JTZ5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C9orf152 | SNV | Missense_Mutation | c.221N>T | p.Ser74Leu | p.S74L | Q5JTZ5 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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