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Gene: C8orf82 |
Gene summary for C8ORF82 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C8orf82 | Gene ID | 414919 |
Gene name | chromosome 8 open reading frame 82 | |
Gene Alias | C8orf82 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q6P1X6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
414919 | C8orf82 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.53e-06 | 2.07e-01 | 0.0155 |
414919 | C8orf82 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.54e-09 | 3.50e-01 | -0.1808 |
414919 | C8orf82 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.57e-08 | 3.34e-01 | -0.0811 |
414919 | C8orf82 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.33e-03 | 2.36e-01 | -0.1088 |
414919 | C8orf82 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.68e-15 | 3.58e-01 | -0.1954 |
414919 | C8orf82 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.10e-10 | 3.93e-01 | -0.1207 |
414919 | C8orf82 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.24e-03 | 3.03e-01 | -0.1526 |
414919 | C8orf82 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.19e-18 | 3.38e-01 | -0.1464 |
414919 | C8orf82 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.10e-06 | 2.15e-01 | -0.1001 |
414919 | C8orf82 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.65e-13 | 3.98e-01 | -0.059 |
414919 | C8orf82 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.41e-09 | 4.49e-01 | -0.0842 |
414919 | C8orf82 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.27e-09 | 2.66e-01 | 0.096 |
414919 | C8orf82 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.71e-05 | 4.35e-01 | 0.0446 |
414919 | C8orf82 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.61e-05 | 6.35e-01 | 0.0451 |
414919 | C8orf82 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.16e-03 | 4.51e-01 | 0.0528 |
414919 | C8orf82 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.70e-04 | 3.29e-01 | 0.0131 |
414919 | C8orf82 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.02e-05 | 3.29e-01 | -0.0177 |
414919 | C8orf82 | HTA11_6801_2000001011 | Human | Colorectum | SER | 9.57e-03 | 3.23e-01 | 0.0171 |
414919 | C8orf82 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.34e-07 | 3.05e-01 | 0.0338 |
414919 | C8orf82 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.04e-16 | 4.17e-01 | 0.0674 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C8orf82 | SNV | Missense_Mutation | novel | c.50N>T | p.Arg17Leu | p.R17L | Q6P1X6 | protein_coding | tolerated(0.71) | benign(0.001) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C8orf82 | SNV | Missense_Mutation | novel | c.236N>A | p.Arg79His | p.R79H | Q6P1X6 | protein_coding | tolerated(0.12) | probably_damaging(0.983) | TCGA-D1-A1NS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C8orf82 | SNV | Missense_Mutation | novel | c.316N>T | p.Arg106Cys | p.R106C | Q6P1X6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C8orf82 | SNV | Missense_Mutation | novel | c.303N>T | p.Glu101Asp | p.E101D | Q6P1X6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C8orf82 | SNV | Missense_Mutation | novel | c.259C>T | p.Arg87Cys | p.R87C | Q6P1X6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C8orf82 | SNV | Missense_Mutation | c.175N>G | p.Lys59Glu | p.K59E | Q6P1X6 | protein_coding | deleterious(0) | benign(0.244) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
C8orf82 | SNV | Missense_Mutation | novel | c.251N>A | p.Arg84His | p.R84H | Q6P1X6 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-77-8143-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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