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Gene: C7orf43 |
Gene summary for C7ORF43 |
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Gene information | Species | Human | Gene symbol | C7orf43 | Gene ID | 55262 |
Gene name | trafficking protein particle complex subunit 14 | |
Gene Alias | C7orf43 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B3KNS5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55262 | C7orf43 | HCC1_Meng | Human | Liver | HCC | 1.07e-06 | 1.77e-02 | 0.0246 |
55262 | C7orf43 | S014 | Human | Liver | HCC | 1.88e-02 | 1.42e-01 | 0.2254 |
55262 | C7orf43 | S015 | Human | Liver | HCC | 1.88e-03 | 2.23e-01 | 0.2375 |
55262 | C7orf43 | S016 | Human | Liver | HCC | 1.06e-04 | 1.61e-01 | 0.2243 |
55262 | C7orf43 | S027 | Human | Liver | HCC | 5.31e-22 | 1.11e+00 | 0.2446 |
55262 | C7orf43 | S028 | Human | Liver | HCC | 2.62e-39 | 1.45e+00 | 0.2503 |
55262 | C7orf43 | S029 | Human | Liver | HCC | 8.36e-45 | 1.69e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C7orf43 | SNV | Missense_Mutation | rs751542273 | c.1091N>A | p.Arg364His | p.R364H | Q8WVR3 | protein_coding | tolerated(0.23) | probably_damaging(0.991) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
C7orf43 | insertion | In_Frame_Ins | novel | c.1057_1058insAAACAGCCAAATTTGGTGCCAGCCCCATCACAGGAG | p.Ser353delinsLysThrAlaLysPheGlyAlaSerProIleThrGlyGly | p.S353delinsKTAKFGASPITGG | Q8WVR3 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C7orf43 | SNV | Missense_Mutation | c.607N>T | p.Arg203Trp | p.R203W | Q8WVR3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C7orf43 | SNV | Missense_Mutation | novel | c.1132T>C | p.Ser378Pro | p.S378P | Q8WVR3 | protein_coding | tolerated(0.06) | possibly_damaging(0.855) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C7orf43 | SNV | Missense_Mutation | c.1264N>T | p.Arg422Cys | p.R422C | Q8WVR3 | protein_coding | tolerated(0.06) | possibly_damaging(0.764) | TCGA-AA-3989-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
C7orf43 | SNV | Missense_Mutation | rs199570229 | c.1610N>A | p.Arg537His | p.R537H | Q8WVR3 | protein_coding | tolerated_low_confidence(0.07) | benign(0.007) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C7orf43 | SNV | Missense_Mutation | c.477N>G | p.Asp159Glu | p.D159E | Q8WVR3 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-CM-5349-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C7orf43 | SNV | Missense_Mutation | novel | c.1175T>C | p.Leu392Pro | p.L392P | Q8WVR3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A01J-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C7orf43 | insertion | Frame_Shift_Ins | novel | c.281_282insG | p.Gly95ArgfsTer55 | p.G95Rfs*55 | Q8WVR3 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
C7orf43 | SNV | Missense_Mutation | novel | c.775C>A | p.Leu259Ile | p.L259I | Q8WVR3 | protein_coding | tolerated(0.2) | probably_damaging(0.978) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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