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Gene: C7orf26 |
Gene summary for C7ORF26 |
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Gene information | Species | Human | Gene symbol | C7orf26 | Gene ID | 79034 |
Gene name | chromosome 7 open reading frame 26 | |
Gene Alias | C7orf26 | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96N11 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79034 | C7orf26 | LZE7T | Human | Esophagus | ESCC | 4.59e-08 | 2.15e-01 | 0.0667 |
79034 | C7orf26 | LZE24T | Human | Esophagus | ESCC | 2.89e-13 | 2.40e-01 | 0.0596 |
79034 | C7orf26 | P1T-E | Human | Esophagus | ESCC | 1.41e-06 | 1.90e-01 | 0.0875 |
79034 | C7orf26 | P2T-E | Human | Esophagus | ESCC | 1.42e-29 | 4.59e-01 | 0.1177 |
79034 | C7orf26 | P4T-E | Human | Esophagus | ESCC | 6.98e-15 | 4.24e-01 | 0.1323 |
79034 | C7orf26 | P5T-E | Human | Esophagus | ESCC | 3.45e-07 | 1.27e-01 | 0.1327 |
79034 | C7orf26 | P8T-E | Human | Esophagus | ESCC | 1.33e-10 | 1.15e-01 | 0.0889 |
79034 | C7orf26 | P9T-E | Human | Esophagus | ESCC | 8.55e-13 | 2.26e-01 | 0.1131 |
79034 | C7orf26 | P10T-E | Human | Esophagus | ESCC | 6.21e-22 | 4.15e-01 | 0.116 |
79034 | C7orf26 | P11T-E | Human | Esophagus | ESCC | 2.60e-21 | 5.56e-01 | 0.1426 |
79034 | C7orf26 | P12T-E | Human | Esophagus | ESCC | 2.83e-16 | 3.52e-01 | 0.1122 |
79034 | C7orf26 | P15T-E | Human | Esophagus | ESCC | 4.91e-22 | 3.15e-01 | 0.1149 |
79034 | C7orf26 | P16T-E | Human | Esophagus | ESCC | 2.43e-22 | 3.68e-01 | 0.1153 |
79034 | C7orf26 | P17T-E | Human | Esophagus | ESCC | 2.09e-02 | 1.87e-01 | 0.1278 |
79034 | C7orf26 | P19T-E | Human | Esophagus | ESCC | 6.25e-05 | 3.54e-01 | 0.1662 |
79034 | C7orf26 | P20T-E | Human | Esophagus | ESCC | 1.95e-19 | 2.45e-01 | 0.1124 |
79034 | C7orf26 | P21T-E | Human | Esophagus | ESCC | 1.37e-10 | 2.07e-01 | 0.1617 |
79034 | C7orf26 | P22T-E | Human | Esophagus | ESCC | 1.76e-14 | 2.92e-01 | 0.1236 |
79034 | C7orf26 | P23T-E | Human | Esophagus | ESCC | 5.23e-13 | 3.05e-01 | 0.108 |
79034 | C7orf26 | P24T-E | Human | Esophagus | ESCC | 1.64e-05 | 1.53e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C7orf26 | SNV | Missense_Mutation | rs778024323 | c.713N>T | p.Thr238Ile | p.T238I | Q96N11 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-AR-A2LN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
C7orf26 | insertion | Frame_Shift_Ins | novel | c.1006_1007insGGTTGATTCTCATCACT | p.Leu336ArgfsTer7 | p.L336Rfs*7 | Q96N11 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
C7orf26 | SNV | Missense_Mutation | rs755583704 | c.958N>A | p.Asp320Asn | p.D320N | Q96N11 | protein_coding | tolerated(0.12) | possibly_damaging(0.879) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C7orf26 | SNV | Missense_Mutation | novel | c.1036N>C | p.Glu346Gln | p.E346Q | Q96N11 | protein_coding | tolerated(0.63) | probably_damaging(0.996) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
C7orf26 | SNV | Missense_Mutation | novel | c.794G>A | p.Gly265Asp | p.G265D | Q96N11 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C7orf26 | SNV | Missense_Mutation | rs760205435 | c.899C>T | p.Thr300Met | p.T300M | Q96N11 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C7orf26 | SNV | Missense_Mutation | c.779N>T | p.Pro260Leu | p.P260L | Q96N11 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C7orf26 | SNV | Missense_Mutation | novel | c.583G>T | p.Asp195Tyr | p.D195Y | Q96N11 | protein_coding | deleterious(0.01) | possibly_damaging(0.66) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C7orf26 | SNV | Missense_Mutation | c.842G>A | p.Arg281Lys | p.R281K | Q96N11 | protein_coding | tolerated(0.48) | benign(0) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C7orf26 | SNV | Missense_Mutation | rs778178395 | c.1177G>A | p.Val393Met | p.V393M | Q96N11 | protein_coding | tolerated_low_confidence(0.09) | probably_damaging(0.995) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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