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Gene: C6orf223 |
Gene summary for C6ORF223 |
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Gene information | Species | Human | Gene symbol | C6orf223 | Gene ID | 221416 |
Gene name | chromosome 6 open reading frame 223 | |
Gene Alias | C6orf223 | |
Cytomap | 6p21.1 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221416 | C6orf223 | HCC2_Meng | Human | Liver | HCC | 5.26e-11 | 1.13e-01 | 0.0107 |
221416 | C6orf223 | S014 | Human | Liver | HCC | 4.98e-10 | 5.79e-01 | 0.2254 |
221416 | C6orf223 | S015 | Human | Liver | HCC | 3.56e-06 | 4.29e-01 | 0.2375 |
221416 | C6orf223 | S016 | Human | Liver | HCC | 7.25e-17 | 8.06e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C6orf223 | SNV | Missense_Mutation | novel | c.517N>C | p.Ser173Pro | p.S173P | Q8N319 | protein_coding | deleterious_low_confidence(0.04) | benign(0.057) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
C6orf223 | deletion | Frame_Shift_Del | novel | c.667delN | p.Asn223IlefsTer64 | p.N223Ifs*64 | Q8N319 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C6orf223 | SNV | Missense_Mutation | novel | c.370N>C | p.Ala124Pro | p.A124P | Q8N319 | protein_coding | tolerated_low_confidence(0.39) | unknown(0) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf223 | SNV | Missense_Mutation | novel | c.560N>A | p.Gly187Asp | p.G187D | Q8N319 | protein_coding | tolerated_low_confidence(0.33) | benign(0.039) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
C6orf223 | SNV | Missense_Mutation | c.539N>A | p.Arg180His | p.R180H | Q8N319 | protein_coding | deleterious_low_confidence(0) | benign(0.312) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C6orf223 | SNV | Missense_Mutation | c.509N>A | p.Arg170Gln | p.R170Q | Q8N319 | protein_coding | tolerated_low_confidence(0.19) | benign(0.389) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C6orf223 | SNV | Missense_Mutation | rs753702926 | c.6G>A | p.Met2Ile | p.M2I | Q8N319 | protein_coding | deleterious_low_confidence(0) | benign(0.031) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C6orf223 | SNV | Missense_Mutation | rs763747720 | c.643N>T | p.Ala215Ser | p.A215S | Q8N319 | protein_coding | tolerated_low_confidence(0.19) | possibly_damaging(0.51) | TCGA-BC-A69I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
C6orf223 | SNV | Missense_Mutation | novel | c.677C>A | p.Pro226Gln | p.P226Q | Q8N319 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.98) | TCGA-G3-A25U-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf223 | deletion | Frame_Shift_Del | novel | c.467_483delNNNNNNNNNNNNNNNNN | p.Pro156GlnfsTer31 | p.P156Qfs*31 | Q8N319 | protein_coding | TCGA-DD-AAEI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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