![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C6orf120 |
Gene summary for C6ORF120 |
![]() |
Gene information | Species | Human | Gene symbol | C6orf120 | Gene ID | 387263 |
Gene name | chromosome 6 open reading frame 120 | |
Gene Alias | C6orf120 | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q7Z4R8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
387263 | C6orf120 | LZE4T | Human | Esophagus | ESCC | 1.99e-04 | 1.67e-01 | 0.0811 |
387263 | C6orf120 | LZE7T | Human | Esophagus | ESCC | 1.23e-04 | 2.38e-01 | 0.0667 |
387263 | C6orf120 | LZE20T | Human | Esophagus | ESCC | 2.35e-03 | 1.40e-01 | 0.0662 |
387263 | C6orf120 | LZE24T | Human | Esophagus | ESCC | 5.55e-17 | 6.38e-01 | 0.0596 |
387263 | C6orf120 | P2T-E | Human | Esophagus | ESCC | 2.85e-07 | 1.34e-01 | 0.1177 |
387263 | C6orf120 | P4T-E | Human | Esophagus | ESCC | 1.32e-06 | 3.12e-01 | 0.1323 |
387263 | C6orf120 | P5T-E | Human | Esophagus | ESCC | 2.74e-17 | 3.05e-01 | 0.1327 |
387263 | C6orf120 | P8T-E | Human | Esophagus | ESCC | 7.32e-07 | 1.69e-01 | 0.0889 |
387263 | C6orf120 | P9T-E | Human | Esophagus | ESCC | 3.32e-12 | 1.30e-01 | 0.1131 |
387263 | C6orf120 | P10T-E | Human | Esophagus | ESCC | 8.21e-06 | 1.78e-01 | 0.116 |
387263 | C6orf120 | P11T-E | Human | Esophagus | ESCC | 7.44e-09 | 2.06e-01 | 0.1426 |
387263 | C6orf120 | P12T-E | Human | Esophagus | ESCC | 1.07e-06 | 1.77e-01 | 0.1122 |
387263 | C6orf120 | P15T-E | Human | Esophagus | ESCC | 7.42e-11 | 2.49e-01 | 0.1149 |
387263 | C6orf120 | P16T-E | Human | Esophagus | ESCC | 1.53e-12 | 2.89e-01 | 0.1153 |
387263 | C6orf120 | P17T-E | Human | Esophagus | ESCC | 1.97e-03 | 1.92e-01 | 0.1278 |
387263 | C6orf120 | P19T-E | Human | Esophagus | ESCC | 1.57e-04 | 6.27e-01 | 0.1662 |
387263 | C6orf120 | P20T-E | Human | Esophagus | ESCC | 2.71e-12 | 2.68e-01 | 0.1124 |
387263 | C6orf120 | P21T-E | Human | Esophagus | ESCC | 1.61e-18 | 4.72e-01 | 0.1617 |
387263 | C6orf120 | P22T-E | Human | Esophagus | ESCC | 5.29e-05 | 1.68e-01 | 0.1236 |
387263 | C6orf120 | P23T-E | Human | Esophagus | ESCC | 7.56e-12 | 3.36e-01 | 0.108 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C6orf120 | SNV | Missense_Mutation | novel | c.144N>C | p.Gln48His | p.Q48H | Q7Z4R8 | protein_coding | tolerated(0.43) | benign(0.067) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
C6orf120 | SNV | Missense_Mutation | novel | c.338C>A | p.Pro113Gln | p.P113Q | Q7Z4R8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf120 | SNV | Missense_Mutation | c.436N>A | p.Glu146Lys | p.E146K | Q7Z4R8 | protein_coding | tolerated(0.48) | benign(0.017) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
C6orf120 | SNV | Missense_Mutation | novel | c.515N>G | p.Glu172Gly | p.E172G | Q7Z4R8 | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf120 | SNV | Missense_Mutation | rs760242279 | c.225N>A | p.Asp75Glu | p.D75E | Q7Z4R8 | protein_coding | deleterious(0) | benign(0.434) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
C6orf120 | SNV | Missense_Mutation | rs774284336 | c.127N>T | p.His43Tyr | p.H43Y | Q7Z4R8 | protein_coding | tolerated(0.15) | possibly_damaging(0.723) | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C6orf120 | SNV | Missense_Mutation | novel | c.568N>A | p.Leu190Ile | p.L190I | Q7Z4R8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf120 | SNV | Missense_Mutation | c.367N>A | p.Ser123Thr | p.S123T | Q7Z4R8 | protein_coding | deleterious(0.03) | probably_damaging(0.971) | TCGA-KR-A7K2-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C6orf120 | SNV | Missense_Mutation | c.454G>A | p.Asp152Asn | p.D152N | Q7Z4R8 | protein_coding | deleterious(0.02) | possibly_damaging(0.56) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C6orf120 | SNV | Missense_Mutation | c.510G>T | p.Glu170Asp | p.E170D | Q7Z4R8 | protein_coding | tolerated(0.3) | benign(0.038) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |