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Gene: C5orf58 |
Gene summary for C5ORF58 |
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Gene information | Species | Human | Gene symbol | C5orf58 | Gene ID | 133874 |
Gene name | chromosome 5 open reading frame 58 | |
Gene Alias | C5orf58 | |
Cytomap | 5q35.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | C9J3I9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
133874 | C5orf58 | S014 | Human | Liver | HCC | 9.54e-27 | 6.41e-01 | 0.2254 |
133874 | C5orf58 | S015 | Human | Liver | HCC | 1.53e-27 | 8.24e-01 | 0.2375 |
133874 | C5orf58 | S016 | Human | Liver | HCC | 1.22e-30 | 7.44e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C5orf58 | SNV | Missense_Mutation | c.18N>C | p.Glu6Asp | p.E6D | C9J3I9 | protein_coding | tolerated_low_confidence(0.11) | benign(0.055) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C5orf58 | SNV | Missense_Mutation | novel | c.229G>A | p.Glu77Lys | p.E77K | C9J3I9 | protein_coding | tolerated(0.05) | possibly_damaging(0.476) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
C5orf58 | SNV | Missense_Mutation | c.134C>A | p.Ser45Tyr | p.S45Y | C9J3I9 | protein_coding | tolerated(0.05) | possibly_damaging(0.799) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
C5orf58 | SNV | Missense_Mutation | novel | c.76C>T | p.Arg26Cys | p.R26C | C9J3I9 | protein_coding | deleterious(0.01) | benign(0.006) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C5orf58 | SNV | Missense_Mutation | c.217G>C | p.Glu73Gln | p.E73Q | C9J3I9 | protein_coding | deleterious(0.04) | possibly_damaging(0.787) | TCGA-EY-A54A-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
C5orf58 | SNV | Missense_Mutation | c.182N>G | p.Asp61Gly | p.D61G | C9J3I9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C5orf58 | SNV | Missense_Mutation | c.60N>C | p.Leu20Phe | p.L20F | C9J3I9 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-49-6745-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | SD | |
C5orf58 | SNV | Missense_Mutation | novel | c.297N>A | p.Ser99Arg | p.S99R | C9J3I9 | protein_coding | tolerated_low_confidence(0.06) | benign(0.003) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
C5orf58 | SNV | Missense_Mutation | c.172T>A | p.Leu58Met | p.L58M | C9J3I9 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C5orf58 | SNV | Missense_Mutation | novel | c.181N>C | p.Asp61His | p.D61H | C9J3I9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D6-A6ES-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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