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Gene: C5orf45 |
Gene summary for C5ORF45 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C5orf45 | Gene ID | 51149 |
| Gene name | MRN complex interacting protein | |
| Gene Alias | C5orf45 | |
| Cytomap | 5q35.3 | |
| Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q6NTE8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51149 | C5orf45 | Dong_P1 | Human | Prostate | Tumor | 2.45e-07 | 9.20e-02 | 0.035 |
| 51149 | C5orf45 | Dong_P3 | Human | Prostate | Tumor | 1.61e-27 | 3.70e-01 | 0.0278 |
| 51149 | C5orf45 | Dong_P4 | Human | Prostate | Tumor | 1.79e-22 | 5.02e-01 | 0.0292 |
| 51149 | C5orf45 | P7 | Human | Prostate | Tumor | 5.49e-10 | 6.39e-01 | -0.1025 |
| 51149 | C5orf45 | P9 | Human | Prostate | Tumor | 1.37e-15 | 5.70e-01 | -0.0285 |
| 51149 | C5orf45 | P10 | Human | Prostate | Tumor | 4.32e-13 | 4.25e-01 | -0.0902 |
| 51149 | C5orf45 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 4.77e-08 | 3.64e-01 | 0.1633 |
| 51149 | C5orf45 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 6.05e-06 | 2.68e-01 | 0.1608 |
| 51149 | C5orf45 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 8.70e-06 | 2.64e-01 | 0.1604 |
| 51149 | C5orf45 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.14e-04 | 2.41e-01 | 0.1621 |
| 51149 | C5orf45 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 2.33e-03 | 2.74e-01 | 0.1602 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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