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Gene: C5orf24 |
Gene summary for C5ORF24 |
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Gene information | Species | Human | Gene symbol | C5orf24 | Gene ID | 134553 |
Gene name | chromosome 5 open reading frame 24 | |
Gene Alias | C5orf24 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q7Z6I8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
134553 | C5orf24 | LZE2T | Human | Esophagus | ESCC | 2.99e-02 | 5.69e-01 | 0.082 |
134553 | C5orf24 | LZE3D | Human | Esophagus | HGIN | 9.94e-04 | 7.21e-01 | 0.0668 |
134553 | C5orf24 | LZE4T | Human | Esophagus | ESCC | 6.36e-06 | 1.54e-01 | 0.0811 |
134553 | C5orf24 | LZE5T | Human | Esophagus | ESCC | 7.83e-03 | 1.54e-01 | 0.0514 |
134553 | C5orf24 | LZE7T | Human | Esophagus | ESCC | 2.88e-05 | 1.91e-01 | 0.0667 |
134553 | C5orf24 | LZE20T | Human | Esophagus | ESCC | 4.84e-06 | 1.13e-01 | 0.0662 |
134553 | C5orf24 | LZE22T | Human | Esophagus | ESCC | 6.81e-05 | 3.88e-01 | 0.068 |
134553 | C5orf24 | LZE24T | Human | Esophagus | ESCC | 1.30e-23 | 6.89e-01 | 0.0596 |
134553 | C5orf24 | LZE21T | Human | Esophagus | ESCC | 1.76e-03 | 1.73e-01 | 0.0655 |
134553 | C5orf24 | P1T-E | Human | Esophagus | ESCC | 1.30e-14 | 5.57e-01 | 0.0875 |
134553 | C5orf24 | P2T-E | Human | Esophagus | ESCC | 2.17e-39 | 7.50e-01 | 0.1177 |
134553 | C5orf24 | P4T-E | Human | Esophagus | ESCC | 2.19e-34 | 6.06e-01 | 0.1323 |
134553 | C5orf24 | P5T-E | Human | Esophagus | ESCC | 1.83e-25 | 5.34e-01 | 0.1327 |
134553 | C5orf24 | P8T-E | Human | Esophagus | ESCC | 1.36e-19 | 3.76e-01 | 0.0889 |
134553 | C5orf24 | P9T-E | Human | Esophagus | ESCC | 9.01e-23 | 5.80e-01 | 0.1131 |
134553 | C5orf24 | P10T-E | Human | Esophagus | ESCC | 1.26e-36 | 7.32e-01 | 0.116 |
134553 | C5orf24 | P11T-E | Human | Esophagus | ESCC | 1.04e-17 | 6.61e-01 | 0.1426 |
134553 | C5orf24 | P12T-E | Human | Esophagus | ESCC | 3.07e-31 | 7.13e-01 | 0.1122 |
134553 | C5orf24 | P15T-E | Human | Esophagus | ESCC | 1.91e-22 | 4.52e-01 | 0.1149 |
134553 | C5orf24 | P16T-E | Human | Esophagus | ESCC | 1.06e-24 | 3.83e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C5orf24 | SNV | Missense_Mutation | c.206N>T | p.Gly69Val | p.G69V | Q7Z6I8 | protein_coding | tolerated_low_confidence(0.62) | benign(0.003) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
C5orf24 | SNV | Missense_Mutation | c.388A>G | p.Lys130Glu | p.K130E | Q7Z6I8 | protein_coding | deleterious(0) | benign(0.057) | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C5orf24 | SNV | Missense_Mutation | c.51N>C | p.Lys17Asn | p.K17N | Q7Z6I8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.991) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C5orf24 | SNV | Missense_Mutation | c.152N>C | p.Met51Thr | p.M51T | Q7Z6I8 | protein_coding | deleterious_low_confidence(0.01) | benign(0.023) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C5orf24 | SNV | Missense_Mutation | novel | c.331N>A | p.Gly111Arg | p.G111R | Q7Z6I8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C5orf24 | SNV | Missense_Mutation | novel | c.109N>C | p.Ser37Pro | p.S37P | Q7Z6I8 | protein_coding | tolerated_low_confidence(0.15) | benign(0.221) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C5orf24 | SNV | Missense_Mutation | rs758397310 | c.457N>A | p.Asp153Asn | p.D153N | Q7Z6I8 | protein_coding | tolerated_low_confidence(0.44) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C5orf24 | SNV | Missense_Mutation | c.268N>T | p.Arg90Cys | p.R90C | Q7Z6I8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C5orf24 | SNV | Missense_Mutation | novel | c.497C>A | p.Pro166His | p.P166H | Q7Z6I8 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.678) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
C5orf24 | SNV | Missense_Mutation | c.225A>C | p.Lys75Asn | p.K75N | Q7Z6I8 | protein_coding | tolerated_low_confidence(0.32) | benign(0.201) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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