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Gene: C5orf15 |
Gene summary for C5ORF15 |
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Gene information | Species | Human | Gene symbol | C5orf15 | Gene ID | 56951 |
Gene name | chromosome 5 open reading frame 15 | |
Gene Alias | HTGN29 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8NC54 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56951 | C5orf15 | LZE4T | Human | Esophagus | ESCC | 6.74e-08 | 2.59e-01 | 0.0811 |
56951 | C5orf15 | LZE8T | Human | Esophagus | ESCC | 1.53e-12 | 3.86e-01 | 0.067 |
56951 | C5orf15 | LZE20T | Human | Esophagus | ESCC | 5.91e-03 | -9.08e-02 | 0.0662 |
56951 | C5orf15 | LZE24T | Human | Esophagus | ESCC | 1.66e-24 | 9.08e-01 | 0.0596 |
56951 | C5orf15 | LZE6T | Human | Esophagus | ESCC | 2.70e-03 | 4.40e-01 | 0.0845 |
56951 | C5orf15 | P1T-E | Human | Esophagus | ESCC | 1.21e-02 | 2.65e-01 | 0.0875 |
56951 | C5orf15 | P2T-E | Human | Esophagus | ESCC | 1.81e-56 | 1.18e+00 | 0.1177 |
56951 | C5orf15 | P4T-E | Human | Esophagus | ESCC | 1.04e-33 | 8.64e-01 | 0.1323 |
56951 | C5orf15 | P5T-E | Human | Esophagus | ESCC | 2.52e-21 | 5.45e-01 | 0.1327 |
56951 | C5orf15 | P8T-E | Human | Esophagus | ESCC | 1.12e-40 | 7.41e-01 | 0.0889 |
56951 | C5orf15 | P9T-E | Human | Esophagus | ESCC | 7.09e-11 | 4.28e-01 | 0.1131 |
56951 | C5orf15 | P10T-E | Human | Esophagus | ESCC | 6.51e-24 | 5.05e-01 | 0.116 |
56951 | C5orf15 | P11T-E | Human | Esophagus | ESCC | 2.60e-21 | 1.23e+00 | 0.1426 |
56951 | C5orf15 | P12T-E | Human | Esophagus | ESCC | 4.15e-46 | 1.08e+00 | 0.1122 |
56951 | C5orf15 | P15T-E | Human | Esophagus | ESCC | 4.70e-35 | 8.58e-01 | 0.1149 |
56951 | C5orf15 | P16T-E | Human | Esophagus | ESCC | 1.10e-44 | 9.40e-01 | 0.1153 |
56951 | C5orf15 | P17T-E | Human | Esophagus | ESCC | 1.17e-08 | 4.82e-01 | 0.1278 |
56951 | C5orf15 | P19T-E | Human | Esophagus | ESCC | 1.44e-11 | 1.08e+00 | 0.1662 |
56951 | C5orf15 | P20T-E | Human | Esophagus | ESCC | 7.74e-17 | 5.87e-01 | 0.1124 |
56951 | C5orf15 | P21T-E | Human | Esophagus | ESCC | 7.51e-29 | 5.45e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C5orf15 | SNV | Missense_Mutation | novel | c.331N>G | p.Leu111Val | p.L111V | Q8NC54 | protein_coding | tolerated(0.69) | benign(0.011) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
C5orf15 | SNV | Missense_Mutation | c.64G>C | p.Ala22Pro | p.A22P | Q8NC54 | protein_coding | deleterious_low_confidence(0.03) | benign(0.029) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C5orf15 | SNV | Missense_Mutation | c.490G>A | p.Glu164Lys | p.E164K | Q8NC54 | protein_coding | tolerated(0.07) | possibly_damaging(0.542) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C5orf15 | SNV | Missense_Mutation | novel | c.565N>C | p.Ser189Pro | p.S189P | Q8NC54 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C5orf15 | SNV | Missense_Mutation | c.788A>T | p.Tyr263Phe | p.Y263F | Q8NC54 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-3902-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C5orf15 | SNV | Missense_Mutation | c.490N>A | p.Glu164Lys | p.E164K | Q8NC54 | protein_coding | tolerated(0.07) | possibly_damaging(0.542) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
C5orf15 | SNV | Missense_Mutation | novel | c.311N>A | p.Pro104His | p.P104H | Q8NC54 | protein_coding | deleterious(0.03) | probably_damaging(0.911) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C5orf15 | SNV | Missense_Mutation | novel | c.484N>A | p.Asp162Asn | p.D162N | Q8NC54 | protein_coding | tolerated(0.07) | probably_damaging(0.989) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C5orf15 | SNV | Missense_Mutation | c.726A>T | p.Glu242Asp | p.E242D | Q8NC54 | protein_coding | tolerated(0.08) | possibly_damaging(0.506) | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD | |
C5orf15 | SNV | Missense_Mutation | novel | c.166N>A | p.Pro56Thr | p.P56T | Q8NC54 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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