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Gene: C4orf48 |
Gene summary for C4ORF48 |
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Gene information | Species | Human | Gene symbol | C4orf48 | Gene ID | 401115 |
Gene name | chromosome 4 open reading frame 48 | |
Gene Alias | CHR4_55 | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401115 | C4orf48 | GSM4909282 | Human | Breast | IDC | 5.20e-08 | -3.92e-01 | -0.0288 |
401115 | C4orf48 | GSM4909285 | Human | Breast | IDC | 3.97e-04 | -1.95e-01 | 0.21 |
401115 | C4orf48 | GSM4909286 | Human | Breast | IDC | 1.77e-08 | 3.70e-02 | 0.1081 |
401115 | C4orf48 | GSM4909293 | Human | Breast | IDC | 1.24e-52 | 8.93e-01 | 0.1581 |
401115 | C4orf48 | GSM4909296 | Human | Breast | IDC | 1.44e-18 | -4.64e-01 | 0.1524 |
401115 | C4orf48 | GSM4909297 | Human | Breast | IDC | 2.23e-02 | 1.94e-02 | 0.1517 |
401115 | C4orf48 | GSM4909298 | Human | Breast | IDC | 2.39e-06 | -3.34e-01 | 0.1551 |
401115 | C4orf48 | GSM4909301 | Human | Breast | IDC | 1.64e-70 | 1.05e+00 | 0.1577 |
401115 | C4orf48 | GSM4909302 | Human | Breast | IDC | 1.69e-05 | 3.71e-01 | 0.1545 |
401115 | C4orf48 | GSM4909306 | Human | Breast | IDC | 1.38e-35 | 7.89e-01 | 0.1564 |
401115 | C4orf48 | GSM4909311 | Human | Breast | IDC | 1.37e-17 | -2.45e-01 | 0.1534 |
401115 | C4orf48 | GSM4909312 | Human | Breast | IDC | 1.15e-05 | -3.33e-01 | 0.1552 |
401115 | C4orf48 | GSM4909313 | Human | Breast | IDC | 7.77e-06 | 2.76e-01 | 0.0391 |
401115 | C4orf48 | GSM4909315 | Human | Breast | IDC | 5.12e-08 | 4.50e-01 | 0.21 |
401115 | C4orf48 | GSM4909316 | Human | Breast | IDC | 1.29e-07 | 4.43e-01 | 0.21 |
401115 | C4orf48 | GSM4909317 | Human | Breast | IDC | 3.33e-05 | 3.88e-01 | 0.1355 |
401115 | C4orf48 | GSM4909318 | Human | Breast | IDC | 2.28e-02 | 9.73e-02 | 0.2031 |
401115 | C4orf48 | GSM4909319 | Human | Breast | IDC | 1.01e-29 | 3.29e-01 | 0.1563 |
401115 | C4orf48 | GSM4909320 | Human | Breast | IDC | 1.71e-02 | -3.85e-02 | 0.1575 |
401115 | C4orf48 | GSM4909321 | Human | Breast | IDC | 4.04e-05 | -2.37e-01 | 0.1559 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C4orf48 | SNV | Missense_Mutation | c.350N>A | p.Arg117His | p.R117H | Q5BLP8 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
C4orf48 | deletion | Frame_Shift_Del | novel | c.351delN | p.Arg118ValfsTer20 | p.R118Vfs*20 | Q5BLP8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C4orf48 | SNV | Missense_Mutation | c.350N>A | p.Arg117His | p.R117H | Q5BLP8 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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