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Gene: C4B |
Gene summary for C4B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C4B | Gene ID | 721 |
| Gene name | complement C4B (Chido blood group) | |
| Gene Alias | C4B1 | |
| Cytomap | 6p21.33 | |
| Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | P0C0L4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 721 | C4B | S014 | Human | Liver | HCC | 8.95e-14 | 5.29e-01 | 0.2254 |
| 721 | C4B | S015 | Human | Liver | HCC | 5.32e-09 | 3.55e-01 | 0.2375 |
| 721 | C4B | S016 | Human | Liver | HCC | 2.68e-06 | 2.37e-01 | 0.2243 |
| 721 | C4B | S027 | Human | Liver | HCC | 2.14e-11 | 6.98e-01 | 0.2446 |
| 721 | C4B | S028 | Human | Liver | HCC | 3.07e-19 | 5.41e-01 | 0.2503 |
| 721 | C4B | S029 | Human | Liver | HCC | 8.23e-25 | 8.22e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00098967 | Liver | NAFLD | positive regulation of catabolic process | 108/1882 | 492/18723 | 2.68e-15 | 3.14e-12 | 108 |
| GO:00421767 | Liver | NAFLD | regulation of protein catabolic process | 83/1882 | 391/18723 | 2.94e-11 | 1.01e-08 | 83 |
| GO:00420607 | Liver | NAFLD | wound healing | 84/1882 | 422/18723 | 6.56e-10 | 1.37e-07 | 84 |
| GO:00075994 | Liver | NAFLD | hemostasis | 49/1882 | 222/18723 | 9.23e-08 | 7.59e-06 | 49 |
| GO:00075964 | Liver | NAFLD | blood coagulation | 48/1882 | 217/18723 | 1.16e-07 | 8.81e-06 | 48 |
| GO:00508174 | Liver | NAFLD | coagulation | 48/1882 | 222/18723 | 2.40e-07 | 1.61e-05 | 48 |
| GO:00457327 | Liver | NAFLD | positive regulation of protein catabolic process | 48/1882 | 231/18723 | 8.22e-07 | 4.45e-05 | 48 |
| GO:00508787 | Liver | NAFLD | regulation of body fluid levels | 60/1882 | 379/18723 | 2.61e-04 | 4.23e-03 | 60 |
| GO:0045916 | Liver | NAFLD | negative regulation of complement activation | 6/1882 | 12/18723 | 5.54e-04 | 7.46e-03 | 6 |
| GO:0030449 | Liver | NAFLD | regulation of complement activation | 8/1882 | 21/18723 | 6.29e-04 | 8.21e-03 | 8 |
| GO:0002921 | Liver | NAFLD | negative regulation of humoral immune response | 6/1882 | 16/18723 | 3.37e-03 | 2.93e-02 | 6 |
| GO:004217612 | Liver | Cirrhotic | regulation of protein catabolic process | 181/4634 | 391/18723 | 7.94e-21 | 2.77e-18 | 181 |
| GO:000989612 | Liver | Cirrhotic | positive regulation of catabolic process | 215/4634 | 492/18723 | 1.13e-20 | 3.56e-18 | 215 |
| GO:004573212 | Liver | Cirrhotic | positive regulation of protein catabolic process | 112/4634 | 231/18723 | 3.89e-15 | 4.21e-13 | 112 |
| GO:004206012 | Liver | Cirrhotic | wound healing | 155/4634 | 422/18723 | 2.12e-08 | 7.56e-07 | 155 |
| GO:000759611 | Liver | Cirrhotic | blood coagulation | 79/4634 | 217/18723 | 8.06e-05 | 8.81e-04 | 79 |
| GO:000759911 | Liver | Cirrhotic | hemostasis | 80/4634 | 222/18723 | 1.08e-04 | 1.10e-03 | 80 |
| GO:005081711 | Liver | Cirrhotic | coagulation | 79/4634 | 222/18723 | 1.90e-04 | 1.76e-03 | 79 |
| GO:005087812 | Liver | Cirrhotic | regulation of body fluid levels | 118/4634 | 379/18723 | 2.65e-03 | 1.55e-02 | 118 |
| GO:000989622 | Liver | HCC | positive regulation of catabolic process | 335/7958 | 492/18723 | 3.83e-31 | 1.87e-28 | 335 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| C4B | SNV | Missense_Mutation | novel | c.3448C>T | p.His1150Tyr | p.H1150Y | P0C0L5 | protein_coding | tolerated(0.13) | benign(0.042) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| C4B | SNV | Missense_Mutation | rs767902266 | c.2605G>A | p.Val869Met | p.V869M | P0C0L5 | protein_coding | tolerated(0.85) | benign(0.149) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| C4B | SNV | Missense_Mutation | c.3695N>T | p.Ser1232Leu | p.S1232L | P0C0L5 | protein_coding | tolerated(0.12) | benign(0.01) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
| C4B | SNV | Missense_Mutation | novel | c.2579N>G | p.Asp860Gly | p.D860G | P0C0L5 | protein_coding | tolerated(0.14) | benign(0.044) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| C4B | SNV | Missense_Mutation | novel | c.3526N>C | p.Ser1176Arg | p.S1176R | P0C0L5 | protein_coding | tolerated(0.31) | benign(0.062) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| C4B | SNV | Missense_Mutation | novel | c.2669N>A | p.Pro890His | p.P890H | P0C0L5 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| C4B | SNV | Missense_Mutation | novel | c.3650T>C | p.Leu1217Pro | p.L1217P | P0C0L5 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| C4B | SNV | Missense_Mutation | novel | c.4046G>A | p.Arg1349His | p.R1349H | P0C0L5 | protein_coding | tolerated(1) | benign(0) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
| C4B | SNV | Missense_Mutation | novel | c.3727N>T | p.Pro1243Ser | p.P1243S | P0C0L5 | protein_coding | tolerated_low_confidence(0.06) | benign(0.012) | TCGA-DM-A28K-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| C4B | SNV | Missense_Mutation | c.3543N>T | p.Glu1181Asp | p.E1181D | P0C0L5 | protein_coding | tolerated(0.57) | benign(0.08) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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