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Gene: C3orf62 |
Gene summary for C3ORF62 |
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Gene information | Species | Human | Gene symbol | C3orf62 | Gene ID | 375341 |
Gene name | chromosome 3 open reading frame 62 | |
Gene Alias | MAPS | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6ZUJ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375341 | C3orf62 | HCC1_Meng | Human | Liver | HCC | 4.79e-16 | 2.84e-02 | 0.0246 |
375341 | C3orf62 | HCC1 | Human | Liver | HCC | 3.38e-02 | 7.69e-01 | 0.5336 |
375341 | C3orf62 | HCC2 | Human | Liver | HCC | 7.89e-17 | 2.59e+00 | 0.5341 |
375341 | C3orf62 | HCC5 | Human | Liver | HCC | 5.76e-08 | 1.98e+00 | 0.4932 |
375341 | C3orf62 | S027 | Human | Liver | HCC | 1.43e-03 | 2.66e-01 | 0.2446 |
375341 | C3orf62 | S028 | Human | Liver | HCC | 7.15e-05 | 2.58e-01 | 0.2503 |
375341 | C3orf62 | S029 | Human | Liver | HCC | 2.01e-04 | 2.62e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C3orf62 | SNV | Missense_Mutation | c.347N>A | p.Ser116Asn | p.S116N | Q6ZUJ4 | protein_coding | tolerated(0.08) | probably_damaging(0.996) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C3orf62 | SNV | Missense_Mutation | c.289N>A | p.His97Asn | p.H97N | Q6ZUJ4 | protein_coding | tolerated(0.24) | benign(0.076) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C3orf62 | SNV | Missense_Mutation | novel | c.427T>C | p.Trp143Arg | p.W143R | Q6ZUJ4 | protein_coding | deleterious(0.01) | possibly_damaging(0.884) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C3orf62 | SNV | Missense_Mutation | c.275N>T | p.Ala92Val | p.A92V | Q6ZUJ4 | protein_coding | tolerated(0.35) | benign(0.025) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C3orf62 | SNV | Missense_Mutation | novel | c.604N>T | p.His202Tyr | p.H202Y | Q6ZUJ4 | protein_coding | deleterious(0) | benign(0.093) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C3orf62 | SNV | Missense_Mutation | novel | c.548N>T | p.Ser183Ile | p.S183I | Q6ZUJ4 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C3orf62 | SNV | Missense_Mutation | novel | c.154G>A | p.Ala52Thr | p.A52T | Q6ZUJ4 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C3orf62 | SNV | Missense_Mutation | rs770343603 | c.554G>A | p.Arg185Gln | p.R185Q | Q6ZUJ4 | protein_coding | tolerated(0.19) | benign(0.077) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
C3orf62 | SNV | Missense_Mutation | novel | c.137G>T | p.Arg46Met | p.R46M | Q6ZUJ4 | protein_coding | deleterious(0.02) | possibly_damaging(0.521) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
C3orf62 | SNV | Missense_Mutation | novel | c.73N>G | p.Thr25Ala | p.T25A | Q6ZUJ4 | protein_coding | tolerated(0.48) | benign(0.011) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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