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Gene: C2orf88 |
Gene summary for C2ORF88 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C2orf88 | Gene ID | 84281 |
| Gene name | chromosome 2 open reading frame 88 | |
| Gene Alias | smAKAP | |
| Cytomap | 2q32.2 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BSF0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84281 | C2orf88 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.15e-19 | 5.70e-01 | 0.0208 |
| 84281 | C2orf88 | H2 | Human | Cervix | HSIL_HPV | 1.21e-17 | 5.45e-01 | 0.0632 |
| 84281 | C2orf88 | T2 | Human | Cervix | CC | 1.38e-03 | 3.82e-01 | 0.0709 |
| 84281 | C2orf88 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.26e-03 | 2.96e-01 | -0.1954 |
| 84281 | C2orf88 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.30e-03 | 6.03e-01 | -0.1706 |
| 84281 | C2orf88 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.83e-05 | 3.44e-01 | 0.294 |
| 84281 | C2orf88 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 8.28e-05 | 1.08e+00 | 0.3487 |
| 84281 | C2orf88 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.44e-15 | 7.76e-01 | 0.281 |
| 84281 | C2orf88 | A002-C-203 | Human | Colorectum | FAP | 3.65e-03 | -1.26e-01 | 0.2786 |
| 84281 | C2orf88 | A001-C-104 | Human | Colorectum | FAP | 8.65e-03 | -1.28e-01 | 0.0184 |
| 84281 | C2orf88 | A002-C-116 | Human | Colorectum | FAP | 5.36e-03 | -1.13e-01 | -0.0452 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| C2orf88 | SNV | Missense_Mutation | c.21N>T | p.Lys7Asn | p.K7N | Q9BSF0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| C2orf88 | SNV | Missense_Mutation | c.92N>C | p.Glu31Ala | p.E31A | Q9BSF0 | protein_coding | deleterious(0.03) | benign(0.359) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
| C2orf88 | SNV | Missense_Mutation | rs777387815 | c.269N>C | p.Ile90Thr | p.I90T | Q9BSF0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
| C2orf88 | SNV | Missense_Mutation | c.37N>T | p.Pro13Ser | p.P13S | Q9BSF0 | protein_coding | tolerated(0.27) | possibly_damaging(0.785) | TCGA-F5-6810-01 | Colorectum | rectum adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown | |
| C2orf88 | SNV | Missense_Mutation | novel | c.152C>A | p.Pro51His | p.P51H | Q9BSF0 | protein_coding | tolerated(0.12) | benign(0.043) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| C2orf88 | SNV | Missense_Mutation | novel | c.256N>T | p.Asp86Tyr | p.D86Y | Q9BSF0 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| C2orf88 | SNV | Missense_Mutation | rs759459884 | c.191N>A | p.Arg64His | p.R64H | Q9BSF0 | protein_coding | tolerated(0.14) | benign(0.011) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| C2orf88 | SNV | Missense_Mutation | novel | c.212N>A | p.Cys71Tyr | p.C71Y | Q9BSF0 | protein_coding | deleterious(0.02) | benign(0) | TCGA-CV-A6JY-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| C2orf88 | SNV | Missense_Mutation | rs780426934 | c.251A>G | p.Tyr84Cys | p.Y84C | Q9BSF0 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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