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Gene: C2orf82 |
Gene summary for C2ORF82 |
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Gene information | Species | Human | Gene symbol | C2orf82 | Gene ID | 389084 |
Gene name | secondary ossification center associated regulator of chondrocyte maturation | |
Gene Alias | ASCL830 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q6UX34 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389084 | C2orf82 | P10T-E | Human | Esophagus | ESCC | 1.74e-35 | 7.96e-01 | 0.116 |
389084 | C2orf82 | P16T-E | Human | Esophagus | ESCC | 2.35e-03 | 1.32e-01 | 0.1153 |
389084 | C2orf82 | P31T-E | Human | Esophagus | ESCC | 5.31e-16 | 3.22e-01 | 0.1251 |
389084 | C2orf82 | P49T-E | Human | Esophagus | ESCC | 3.75e-07 | 5.33e-01 | 0.1768 |
389084 | C2orf82 | P74T-E | Human | Esophagus | ESCC | 3.81e-05 | 1.48e-01 | 0.1479 |
389084 | C2orf82 | P76T-E | Human | Esophagus | ESCC | 6.38e-08 | 4.56e-01 | 0.1207 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C2orf82 | SNV | Missense_Mutation | novel | c.4N>A | p.Ala2Thr | p.A2T | Q6UX34 | protein_coding | deleterious_low_confidence(0.02) | benign(0.015) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C2orf82 | SNV | Missense_Mutation | novel | c.279N>G | p.Ile93Met | p.I93M | Q6UX34 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-T3-A92N-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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