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Gene: C21orf58 |
Gene summary for C21ORF58 |
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Gene information | Species | Human | Gene symbol | C21orf58 | Gene ID | 54058 |
Gene name | chromosome 21 open reading frame 58 | |
Gene Alias | C21orf58 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | P58505 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54058 | C21orf58 | HCC1_Meng | Human | Liver | HCC | 2.68e-06 | 1.36e-02 | 0.0246 |
54058 | C21orf58 | HCC2 | Human | Liver | HCC | 2.91e-02 | 1.15e+00 | 0.5341 |
54058 | C21orf58 | HCC5 | Human | Liver | HCC | 7.23e-03 | 2.53e+00 | 0.4932 |
54058 | C21orf58 | S028 | Human | Liver | HCC | 3.28e-09 | 3.32e-01 | 0.2503 |
54058 | C21orf58 | S029 | Human | Liver | HCC | 2.14e-02 | 1.60e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C21orf58 | SNV | Missense_Mutation | rs377051341 | c.386C>T | p.Pro129Leu | p.P129L | P58505 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
C21orf58 | SNV | Missense_Mutation | c.256G>C | p.Asp86His | p.D86H | P58505 | protein_coding | deleterious(0.03) | possibly_damaging(0.46) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C21orf58 | SNV | Missense_Mutation | c.128C>G | p.Pro43Arg | p.P43R | P58505 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.758) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
C21orf58 | SNV | Missense_Mutation | novel | c.158N>G | p.Ala53Gly | p.A53G | P58505 | protein_coding | deleterious_low_confidence(0.01) | benign(0.014) | TCGA-VS-A9V0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
C21orf58 | SNV | Missense_Mutation | c.419G>C | p.Arg140Thr | p.R140T | P58505 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
C21orf58 | SNV | Missense_Mutation | c.596N>C | p.Ile199Thr | p.I199T | P58505 | protein_coding | deleterious(0) | possibly_damaging(0.725) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C21orf58 | SNV | Missense_Mutation | c.422N>T | p.Arg141Met | p.R141M | P58505 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C21orf58 | SNV | Missense_Mutation | c.764A>C | p.Gln255Pro | p.Q255P | P58505 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C21orf58 | SNV | Missense_Mutation | rs373559696 | c.685N>A | p.Ala229Thr | p.A229T | P58505 | protein_coding | tolerated(0.08) | benign(0.147) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
C21orf58 | deletion | Frame_Shift_Del | c.540delN | p.Thr181ArgfsTer41 | p.T181Rfs*41 | P58505 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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