Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: C20orf27

Gene summary for C20ORF27

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

C20orf27

Gene ID

54976

Gene namechromosome 20 open reading frame 27
Gene AliasC20orf27
Cytomap20p13
Gene Typeprotein-coding
GO ID

GO:0007154

UniProtAcc

Q9GZN8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
54976C20orf27AEH-subject1HumanEndometriumAEH5.29e-31-5.18e-01-0.3059
54976C20orf27AEH-subject2HumanEndometriumAEH2.82e-19-4.57e-01-0.2525
54976C20orf27AEH-subject3HumanEndometriumAEH1.20e-20-4.74e-01-0.2576
54976C20orf27AEH-subject4HumanEndometriumAEH3.12e-18-4.89e-01-0.2657
54976C20orf27AEH-subject5HumanEndometriumAEH3.30e-19-4.71e-01-0.2953
54976C20orf27EEC-subject1HumanEndometriumEEC2.79e-23-4.84e-01-0.2682
54976C20orf27EEC-subject2HumanEndometriumEEC3.21e-25-5.05e-01-0.2607
54976C20orf27EEC-subject3HumanEndometriumEEC3.81e-38-4.79e-01-0.2525
54976C20orf27EEC-subject4HumanEndometriumEEC5.12e-16-4.25e-01-0.2571
54976C20orf27EEC-subject5HumanEndometriumEEC4.99e-19-4.59e-01-0.249
54976C20orf27GSM5276934HumanEndometriumEEC2.02e-10-3.26e-01-0.0913
54976C20orf27GSM5276935HumanEndometriumEEC1.28e-11-4.07e-01-0.123
54976C20orf27GSM5276937HumanEndometriumEEC6.50e-16-4.45e-01-0.0897
54976C20orf27GSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC6.61e-25-4.49e-01-0.1869
54976C20orf27GSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC2.57e-20-5.08e-01-0.1875
54976C20orf27GSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC9.09e-24-4.16e-01-0.1883
54976C20orf27GSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC1.24e-26-4.01e-01-0.1934
54976C20orf27GSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC1.89e-29-5.01e-01-0.1917
54976C20orf27GSM6177622_NYU_UCEC3_lib2_lib2HumanEndometriumEEC2.01e-38-4.40e-01-0.1916
54976C20orf27GSM6177623_NYU_UCEC3_VisHumanEndometriumEEC3.54e-04-2.49e-01-0.1269
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00715596EndometriumAEHresponse to transforming growth factor beta53/2100256/187237.01e-061.69e-0453
GO:00071787EndometriumAEHtransmembrane receptor protein serine/threonine kinase signaling pathway67/2100355/187231.28e-052.80e-0467
GO:00715606EndometriumAEHcellular response to transforming growth factor beta stimulus51/2100250/187231.59e-053.32e-0451
GO:00071796EndometriumAEHtransforming growth factor beta receptor signaling pathway38/2100198/187236.41e-046.23e-0338
GO:19012244EndometriumAEHpositive regulation of NIK/NF-kappaB signaling17/210069/187231.30e-031.11e-0217
GO:00900922EndometriumAEHregulation of transmembrane receptor protein serine/threonine kinase signaling pathway43/2100256/187234.47e-032.93e-0243
GO:007155914EndometriumEECresponse to transforming growth factor beta54/2168256/187238.25e-061.83e-0454
GO:007156014EndometriumEECcellular response to transforming growth factor beta stimulus52/2168250/187231.81e-053.41e-0452
GO:000717814EndometriumEECtransmembrane receptor protein serine/threonine kinase signaling pathway68/2168355/187231.90e-053.50e-0468
GO:190122411EndometriumEECpositive regulation of NIK/NF-kappaB signaling19/216869/187232.27e-042.70e-0319
GO:000717914EndometriumEECtransforming growth factor beta receptor signaling pathway39/2168198/187236.03e-045.98e-0339
GO:19012222EndometriumEECregulation of NIK/NF-kappaB signaling24/2168112/187232.00e-031.51e-0224
GO:009009211EndometriumEECregulation of transmembrane receptor protein serine/threonine kinase signaling pathway44/2168256/187234.72e-033.00e-0244
GO:00380612EndometriumEECNIK/NF-kappaB signaling27/2168143/187236.99e-034.01e-0227
GO:19012247EsophagusHGINpositive regulation of NIK/NF-kappaB signaling18/258769/187234.94e-034.18e-0218
GO:00715599EsophagusESCCresponse to transforming growth factor beta157/8552256/187232.95e-074.23e-06157
GO:00715609EsophagusESCCcellular response to transforming growth factor beta stimulus151/8552250/187231.78e-062.10e-05151
GO:00071799EsophagusESCCtransforming growth factor beta receptor signaling pathway121/8552198/187238.26e-068.03e-05121
GO:000717810EsophagusESCCtransmembrane receptor protein serine/threonine kinase signaling pathway195/8552355/187232.58e-041.58e-03195
GO:00305115EsophagusESCCpositive regulation of transforming growth factor beta receptor signaling pathway24/855232/187237.22e-043.77e-0324
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
C20orf27insertionNonsense_Mutationnovelc.165_166insACCTGAGTTTCTTTTCTCTCAAGTGGAGACAATp.Val55_His56insThrTerValSerPheLeuSerSerGlyAspAsnp.V55_H56insT*VSFLSSGDNQ9GZN8protein_codingTCGA-AO-A0JB-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
C20orf27deletionFrame_Shift_Delnovelc.78delNp.Arg27GlyfsTer57p.R27Gfs*57Q9GZN8protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
C20orf27SNVMissense_Mutationc.283N>Gp.Leu95Valp.L95VQ9GZN8protein_codingtolerated(0.15)benign(0.391)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
C20orf27SNVMissense_Mutationrs746348018c.155A>Cp.His52Prop.H52PQ9GZN8protein_codingtolerated(0.38)benign(0)TCGA-AA-3851-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
C20orf27SNVMissense_Mutationnovelc.212N>Gp.Glu71Glyp.E71GQ9GZN8protein_codingdeleterious(0.02)possibly_damaging(0.744)TCGA-DM-A1DA-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownSD
C20orf27SNVMissense_Mutationnovelc.374N>Cp.Glu125Alap.E125AQ9GZN8protein_codingdeleterious(0.01)benign(0.219)TCGA-AX-A0J0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
C20orf27SNVMissense_Mutationrs746711207c.491N>Ap.Arg164Hisp.R164HQ9GZN8protein_codingdeleterious(0)probably_damaging(0.982)TCGA-AX-A0J1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
C20orf27SNVMissense_Mutationrs752711158c.122N>Ap.Arg41Hisp.R41HQ9GZN8protein_codingtolerated(0.06)possibly_damaging(0.528)TCGA-B5-A11E-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
C20orf27SNVMissense_Mutationnovelc.514N>Gp.Thr172Alap.T172AQ9GZN8protein_codingdeleterious(0)possibly_damaging(0.719)TCGA-DF-A2KN-01Endometriumuterine corpus endometrioid carcinomaFemaleUnknownI/IIUnknownUnknownSD
C20orf27SNVMissense_Mutationnovelc.542N>Ap.Cys181Tyrp.C181YQ9GZN8protein_codingdeleterious(0)probably_damaging(0.987)TCGA-EO-A22U-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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