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Gene: C20orf24 |
Gene summary for C20ORF24 |
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Gene information | Species | Human | Gene symbol | C20orf24 | Gene ID | 55969 |
Gene name | RAB5 interacting factor | |
Gene Alias | C20orf24 | |
Cytomap | 20q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9BUV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55969 | C20orf24 | P1T-E | Human | Esophagus | ESCC | 2.41e-13 | 1.43e+00 | 0.0875 |
55969 | C20orf24 | P2T-E | Human | Esophagus | ESCC | 2.32e-73 | 1.32e+00 | 0.1177 |
55969 | C20orf24 | P4T-E | Human | Esophagus | ESCC | 1.31e-75 | 2.13e+00 | 0.1323 |
55969 | C20orf24 | P5T-E | Human | Esophagus | ESCC | 4.36e-78 | 1.76e+00 | 0.1327 |
55969 | C20orf24 | P8T-E | Human | Esophagus | ESCC | 9.52e-79 | 2.15e+00 | 0.0889 |
55969 | C20orf24 | P9T-E | Human | Esophagus | ESCC | 6.10e-66 | 2.02e+00 | 0.1131 |
55969 | C20orf24 | P10T-E | Human | Esophagus | ESCC | 4.26e-89 | 1.61e+00 | 0.116 |
55969 | C20orf24 | P11T-E | Human | Esophagus | ESCC | 1.73e-35 | 1.90e+00 | 0.1426 |
55969 | C20orf24 | P12T-E | Human | Esophagus | ESCC | 2.31e-68 | 1.47e+00 | 0.1122 |
55969 | C20orf24 | P15T-E | Human | Esophagus | ESCC | 5.21e-82 | 2.68e+00 | 0.1149 |
55969 | C20orf24 | P16T-E | Human | Esophagus | ESCC | 5.25e-65 | 1.47e+00 | 0.1153 |
55969 | C20orf24 | P17T-E | Human | Esophagus | ESCC | 1.12e-19 | 1.29e+00 | 0.1278 |
55969 | C20orf24 | P19T-E | Human | Esophagus | ESCC | 4.86e-20 | 2.26e+00 | 0.1662 |
55969 | C20orf24 | P20T-E | Human | Esophagus | ESCC | 1.36e-83 | 2.11e+00 | 0.1124 |
55969 | C20orf24 | P21T-E | Human | Esophagus | ESCC | 3.44e-112 | 3.32e+00 | 0.1617 |
55969 | C20orf24 | P22T-E | Human | Esophagus | ESCC | 8.74e-106 | 2.03e+00 | 0.1236 |
55969 | C20orf24 | P23T-E | Human | Esophagus | ESCC | 1.21e-68 | 2.30e+00 | 0.108 |
55969 | C20orf24 | P24T-E | Human | Esophagus | ESCC | 3.00e-72 | 1.82e+00 | 0.1287 |
55969 | C20orf24 | P26T-E | Human | Esophagus | ESCC | 2.21e-112 | 2.47e+00 | 0.1276 |
55969 | C20orf24 | P27T-E | Human | Esophagus | ESCC | 2.62e-45 | 1.09e+00 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C20orf24 | SNV | Missense_Mutation | rs190742083 | c.331N>T | p.Arg111Cys | p.R111C | Q9BUV8 | protein_coding | deleterious_low_confidence(0.05) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C20orf24 | deletion | Frame_Shift_Del | novel | c.273delN | p.Pro92GlnfsTer12 | p.P92Qfs*12 | Q9BUV8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C20orf24 | deletion | Frame_Shift_Del | novel | c.244delN | p.Pro82HisfsTer4 | p.P82Hfs*4 | Q9BUV8 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
C20orf24 | SNV | Missense_Mutation | c.317N>T | p.Ala106Val | p.A106V | Q9BUV8 | protein_coding | tolerated_low_confidence(0.51) | benign(0.34) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
C20orf24 | SNV | Missense_Mutation | rs376043012 | c.385G>A | p.Glu129Lys | p.E129K | Q9BUV8 | protein_coding | tolerated_low_confidence(0.24) | possibly_damaging(0.838) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C20orf24 | SNV | Missense_Mutation | novel | c.321N>T | p.Gln107His | p.Q107H | Q9BUV8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.983) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
C20orf24 | SNV | Missense_Mutation | novel | c.146N>T | p.Arg49Leu | p.R49L | Q9BUV8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
C20orf24 | deletion | Frame_Shift_Del | rs779771385 | c.125delT | p.Leu42Ter | p.L42* | Q9BUV8 | protein_coding | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
C20orf24 | SNV | Missense_Mutation | novel | c.309N>C | p.Leu103Phe | p.L103F | Q9BUV8 | protein_coding | tolerated_low_confidence(0.33) | benign(0.245) | TCGA-CQ-7063-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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