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Gene: C20orf196 |
Gene summary for C20ORF196 |
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Gene information | Species | Human | Gene symbol | C20orf196 | Gene ID | 149840 |
Gene name | shieldin complex subunit 1 | |
Gene Alias | C20orf196 | |
Cytomap | 20p12.3 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q8IYI0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
149840 | C20orf196 | P1T-E | Human | Esophagus | ESCC | 3.21e-03 | 1.82e-01 | 0.0875 |
149840 | C20orf196 | P2T-E | Human | Esophagus | ESCC | 2.09e-11 | 2.72e-01 | 0.1177 |
149840 | C20orf196 | P4T-E | Human | Esophagus | ESCC | 7.43e-13 | 2.82e-01 | 0.1323 |
149840 | C20orf196 | P5T-E | Human | Esophagus | ESCC | 1.43e-07 | 2.03e-01 | 0.1327 |
149840 | C20orf196 | P8T-E | Human | Esophagus | ESCC | 4.75e-18 | 2.81e-01 | 0.0889 |
149840 | C20orf196 | P9T-E | Human | Esophagus | ESCC | 3.65e-09 | 2.00e-01 | 0.1131 |
149840 | C20orf196 | P10T-E | Human | Esophagus | ESCC | 2.45e-19 | 3.58e-01 | 0.116 |
149840 | C20orf196 | P11T-E | Human | Esophagus | ESCC | 8.49e-05 | 2.15e-01 | 0.1426 |
149840 | C20orf196 | P12T-E | Human | Esophagus | ESCC | 5.03e-11 | 1.64e-01 | 0.1122 |
149840 | C20orf196 | P15T-E | Human | Esophagus | ESCC | 2.45e-12 | 2.41e-01 | 0.1149 |
149840 | C20orf196 | P16T-E | Human | Esophagus | ESCC | 4.12e-07 | 1.68e-01 | 0.1153 |
149840 | C20orf196 | P17T-E | Human | Esophagus | ESCC | 6.36e-06 | 2.47e-01 | 0.1278 |
149840 | C20orf196 | P20T-E | Human | Esophagus | ESCC | 3.51e-13 | 2.80e-01 | 0.1124 |
149840 | C20orf196 | P21T-E | Human | Esophagus | ESCC | 3.10e-10 | 2.48e-01 | 0.1617 |
149840 | C20orf196 | P22T-E | Human | Esophagus | ESCC | 4.94e-02 | 8.05e-02 | 0.1236 |
149840 | C20orf196 | P23T-E | Human | Esophagus | ESCC | 8.81e-14 | 3.41e-01 | 0.108 |
149840 | C20orf196 | P24T-E | Human | Esophagus | ESCC | 7.66e-04 | 1.44e-01 | 0.1287 |
149840 | C20orf196 | P26T-E | Human | Esophagus | ESCC | 5.98e-18 | 3.50e-01 | 0.1276 |
149840 | C20orf196 | P27T-E | Human | Esophagus | ESCC | 7.71e-18 | 1.18e-01 | 0.1055 |
149840 | C20orf196 | P28T-E | Human | Esophagus | ESCC | 2.32e-02 | 7.84e-02 | 0.1149 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C20orf196 | SNV | Missense_Mutation | c.542A>C | p.Asp181Ala | p.D181A | Q8IYI0 | protein_coding | tolerated(0.07) | benign(0.027) | TCGA-AR-A1AW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | |
C20orf196 | SNV | Missense_Mutation | novel | c.8N>G | p.Ala3Gly | p.A3G | Q8IYI0 | protein_coding | tolerated(0.78) | benign(0.001) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C20orf196 | SNV | Missense_Mutation | rs765359438 | c.109G>A | p.Glu37Lys | p.E37K | Q8IYI0 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-GM-A2DL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
C20orf196 | SNV | Missense_Mutation | c.65N>T | p.Ser22Leu | p.S22L | Q8IYI0 | protein_coding | deleterious(0.03) | benign(0.078) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
C20orf196 | SNV | Missense_Mutation | c.121N>A | p.Glu41Lys | p.E41K | Q8IYI0 | protein_coding | tolerated(0.08) | possibly_damaging(0.482) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
C20orf196 | SNV | Missense_Mutation | rs761567360 | c.88G>A | p.Val30Ile | p.V30I | Q8IYI0 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C20orf196 | SNV | Missense_Mutation | c.384A>T | p.Lys128Asn | p.K128N | Q8IYI0 | protein_coding | deleterious(0) | possibly_damaging(0.714) | TCGA-NH-A8F8-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
C20orf196 | SNV | Missense_Mutation | c.303A>T | p.Arg101Ser | p.R101S | Q8IYI0 | protein_coding | tolerated(0.64) | benign(0.294) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C20orf196 | SNV | Missense_Mutation | novel | c.199G>A | p.Glu67Lys | p.E67K | Q8IYI0 | protein_coding | tolerated(0.06) | benign(0.234) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
C20orf196 | SNV | Missense_Mutation | novel | c.148N>A | p.Ser50Thr | p.S50T | Q8IYI0 | protein_coding | tolerated(0.27) | possibly_damaging(0.66) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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